• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

牛磺酸抑制诱导型 NADPH 氧化酶依赖性中性粒细胞细胞外陷阱的 TAK1/MAPK 信号通路。

Taurine inhibits induced NADPH oxidase-dependent neutrophil extracellular traps TAK1/MAPK signaling pathways.

机构信息

Ministry of Education Joint International Research Laboratory of Animal Health and Food Safety, Key Laboratory of Animal Physiology & Biochemistry, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.

National Research Center for Veterinary Vaccine Engineering and Technology of China, Jiangsu Academy of Agricultural Sciences, Nanjing, China.

出版信息

Front Immunol. 2022 Aug 25;13:927215. doi: 10.3389/fimmu.2022.927215. eCollection 2022.

DOI:10.3389/fimmu.2022.927215
PMID:36148229
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9488113/
Abstract

Neutrophil extracellular traps (NETs) are produced by neutrophil activation and usually have both anti-infective and pro-damage effects. (), one of the common causative organisms of mastitis, can lead to the production of NETs. Taurine, a free amino acid abundant in the organism, has been shown to have immunomodulatory effects. In this study, we investigated the molecular mechanisms of -induced NETs formation and the regulatory role of taurine. The results showed that NETs had a disruptive effect on mammary epithelial cells and barriers, but do not significantly inhibit the proliferation of . induced NADPH oxidase-dependent NETs. TLR2-mediated activation of the MAPK signaling pathway was involved in this process. Taurine could inhibit the activation of MAPK signaling pathway and NADPH oxidase by modulating the activity of TAK1, thereby inhibiting the production of ROS and NETs. The effects of taurine on NADPH oxidase and NETs in infection were also demonstrated . These results suggest that taurine can protect mammary epithelial cells and barriers from damage by reducing -induced NETs. These data provide new insights and strategies for the prevention and control of mastitis.

摘要

中性粒细胞胞外诱捕网（NETs）是由中性粒细胞激活产生的，通常具有抗感染和促损伤双重作用。（）是乳腺炎的常见病原体之一，可导致 NETs 的产生。牛磺酸是一种在生物体内丰富的游离氨基酸，具有免疫调节作用。在这项研究中，我们研究了 -诱导的 NETs 形成的分子机制以及牛磺酸的调节作用。结果表明，NETs 对乳腺上皮细胞和屏障具有破坏作用，但对 的增殖没有明显抑制作用。诱导的 NADPH 氧化酶依赖性 NETs 。TLR2 介导的 MAPK 信号通路的激活参与了这一过程。牛磺酸通过调节 TAK1 的活性来抑制 MAPK 信号通路和 NADPH 氧化酶的激活，从而抑制 ROS 和 NETs 的产生。牛磺酸对 感染中 NADPH 氧化酶和 NETs 的作用也得到了证实。这些结果表明，牛磺酸可以通过减少 -诱导的 NETs 来保护乳腺上皮细胞和屏障免受损伤。这些数据为乳腺炎的预防和控制提供了新的见解和策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/998b/9488113/167dbdcfd2c7/fimmu-13-927215-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/998b/9488113/0a5f2dc1d171/fimmu-13-927215-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/998b/9488113/185320147a64/fimmu-13-927215-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/998b/9488113/d771373019ee/fimmu-13-927215-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/998b/9488113/77f768e0a0f8/fimmu-13-927215-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/998b/9488113/21def98d8e85/fimmu-13-927215-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/998b/9488113/580a43aecb4a/fimmu-13-927215-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/998b/9488113/167dbdcfd2c7/fimmu-13-927215-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/998b/9488113/0a5f2dc1d171/fimmu-13-927215-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/998b/9488113/185320147a64/fimmu-13-927215-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/998b/9488113/d771373019ee/fimmu-13-927215-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/998b/9488113/77f768e0a0f8/fimmu-13-927215-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/998b/9488113/21def98d8e85/fimmu-13-927215-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/998b/9488113/580a43aecb4a/fimmu-13-927215-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/998b/9488113/167dbdcfd2c7/fimmu-13-927215-g007.jpg

相似文献

1
Taurine inhibits induced NADPH oxidase-dependent neutrophil extracellular traps TAK1/MAPK signaling pathways.牛磺酸抑制诱导型 NADPH 氧化酶依赖性中性粒细胞细胞外陷阱的 TAK1/MAPK 信号通路。
Front Immunol. 2022 Aug 25;13:927215. doi: 10.3389/fimmu.2022.927215. eCollection 2022.
2
Taurine reduction of injury from neutrophil infiltration ameliorates Streptococcus uberis-induced mastitis.牛磺酸减轻中性粒细胞浸润所致损伤可改善乳房链球菌引起的乳腺炎。
Int Immunopharmacol. 2023 Nov;124(Pt B):111028. doi: 10.1016/j.intimp.2023.111028. Epub 2023 Oct 17.
3
The role of NADPH oxidase in taurine attenuation of Streptococcus uberis-induced mastitis in rats.NADPH 氧化酶在牛磺酸减轻大鼠金黄色葡萄球菌性乳腺炎中的作用。
Int Immunopharmacol. 2013 Aug;16(4):429-35. doi: 10.1016/j.intimp.2013.05.007. Epub 2013 May 26.
4
NADPH oxidase-derived reactive oxygen species production activates the ERK1/2 pathway in neutrophil extracellular traps formation by Streptococcus agalactiae isolated from clinical mastitis bovine.来源于烟酰胺腺嘌呤二核苷酸磷酸氧化酶的活性氧生成通过从临床乳腺炎奶牛中分离出的无乳链球菌在中性粒细胞胞外诱捕网形成过程中激活细胞外信号调节激酶1/2通路。
Vet Microbiol. 2022 May;268:109427. doi: 10.1016/j.vetmic.2022.109427. Epub 2022 Apr 4.
5
Taurine protects blood-milk barrier integrity via limiting inflammatory response in Streptococcus uberis infections.牛磺酸通过限制唾液链球菌感染中的炎症反应来保护血乳屏障的完整性。
Int Immunopharmacol. 2021 Dec;101(Pt B):108371. doi: 10.1016/j.intimp.2021.108371. Epub 2021 Nov 15.
6
Serotype 2 Stimulates Neutrophil Extracellular Traps Formation via Activation of p38 MAPK and ERK1/2.血清型 2 通过激活 p38 MAPK 和 ERK1/2 刺激中性粒细胞细胞外陷阱的形成。
Front Immunol. 2018 Dec 7;9:2854. doi: 10.3389/fimmu.2018.02854. eCollection 2018.
7
Bovine neutrophils stimulated with Streptococcus uberis induce neutrophil extracellular traps, and cause cytotoxicity and transcriptional upregulation of inflammatory cytokine genes in bovine mammary epithelial cells.牛乳腺上皮细胞中，被无乳链球菌刺激的牛中性粒细胞可诱导形成中性粒细胞胞外诱捕网，导致细胞毒性和炎症细胞因子基因的转录上调。
J Vet Med Sci. 2024 Feb 8;86(2):141-149. doi: 10.1292/jvms.23-0302. Epub 2023 Dec 18.
8
Toxoplasma gondii-induced neutrophil extracellular traps are relevant to glycolysis, TLR2, and TLR4 MAPK signaling pathway in goats.弓形虫诱导的中性粒细胞胞外陷阱与山羊的糖酵解、TLR2和TLR4 MAPK信号通路有关。
Parasitol Res. 2023 Dec 13;123(1):34. doi: 10.1007/s00436-023-08041-9.
9
TLR2 Signaling Pathway Combats Infection by Inducing Mitochondrial Reactive Oxygen Species Production.TLR2 信号通路通过诱导线粒体活性氧产生来抵抗感染。
Cells. 2020 Feb 21;9(2):494. doi: 10.3390/cells9020494.
10
Taurine Reprograms Mammary-Gland Metabolism and Alleviates Inflammation Induced by in Mice.牛磺酸重塑乳腺代谢并缓解 诱导的小鼠炎症。
Front Immunol. 2021 Jun 10;12:696101. doi: 10.3389/fimmu.2021.696101. eCollection 2021.

引用本文的文献

1
Neutrophil Extracellular Trap Formation Model Induced by Monosodium Urate and Phorbol Myristate Acetate: Involvement in MAPK Signaling Pathways.尿酸单钠和佛波酯诱导的中性粒细胞胞外陷阱形成模型：与丝裂原活化蛋白激酶信号通路的关系
Int J Mol Sci. 2024 Dec 27;26(1):143. doi: 10.3390/ijms26010143.
2
Neutrophil extracellular traps in homeostasis and disease.中性粒细胞胞外陷阱在稳态和疾病中的作用。
Signal Transduct Target Ther. 2024 Sep 20;9(1):235. doi: 10.1038/s41392-024-01933-x.
3
Increased neutrophil extracellular trap formation in oligoarticular, polyarticular juvenile idiopathic arthritis and enthesitis-related arthritis: biomarkers for diagnosis and disease activity.

本文引用的文献

1
NADPH oxidase-derived reactive oxygen species production activates the ERK1/2 pathway in neutrophil extracellular traps formation by Streptococcus agalactiae isolated from clinical mastitis bovine.来源于烟酰胺腺嘌呤二核苷酸磷酸氧化酶的活性氧生成通过从临床乳腺炎奶牛中分离出的无乳链球菌在中性粒细胞胞外诱捕网形成过程中激活细胞外信号调节激酶1/2通路。
Vet Microbiol. 2022 May;268:109427. doi: 10.1016/j.vetmic.2022.109427. Epub 2022 Apr 4.
2
Molecular Prerequisites for Neutrophil Extracellular Trap Formation and Evasion Mechanisms of .中性粒细胞胞外陷阱形成的分子前提条件和 的逃避机制。
Front Immunol. 2022 Feb 14;13:836278. doi: 10.3389/fimmu.2022.836278. eCollection 2022.
3
寡关节型、多关节型幼年特发性关节炎和附着点相关关节炎中性粒细胞胞外诱捕网形成增加：诊断和疾病活动的生物标志物。
Front Immunol. 2024 Aug 9;15:1436193. doi: 10.3389/fimmu.2024.1436193. eCollection 2024.
4
Ginseng-derived nanoparticles alleviate inflammatory bowel disease via the TLR4/MAPK and p62/Nrf2/Keap1 pathways.人参衍生的纳米颗粒通过TLR4/MAPK和p62/Nrf2/Keap1途径减轻炎症性肠病。
J Nanobiotechnology. 2024 Feb 1;22(1):48. doi: 10.1186/s12951-024-02313-x.
5
Bovine neutrophils stimulated with Streptococcus uberis induce neutrophil extracellular traps, and cause cytotoxicity and transcriptional upregulation of inflammatory cytokine genes in bovine mammary epithelial cells.牛乳腺上皮细胞中，被无乳链球菌刺激的牛中性粒细胞可诱导形成中性粒细胞胞外诱捕网，导致细胞毒性和炎症细胞因子基因的转录上调。
J Vet Med Sci. 2024 Feb 8;86(2):141-149. doi: 10.1292/jvms.23-0302. Epub 2023 Dec 18.
6
Functional Role of Taurine in Aging and Cardiovascular Health: An Updated Overview.牛磺酸在衰老和心血管健康中的功能作用：最新综述。
Nutrients. 2023 Sep 30;15(19):4236. doi: 10.3390/nu15194236.
7
Gut microbiota aggravates neutrophil extracellular traps-induced pancreatic injury in hypertriglyceridemic pancreatitis.肠道微生物群加剧了高脂血症性胰腺炎中中性粒细胞胞外诱捕网诱导的胰腺损伤。
Nat Commun. 2023 Oct 4;14(1):6179. doi: 10.1038/s41467-023-41950-y.
8
Combination of Taurine and Black Pepper Extract as a Treatment for Cardiovascular and Coronary Artery Diseases.牛磺酸和黑胡椒提取物联合治疗心血管疾病和冠状动脉疾病。
Nutrients. 2023 May 30;15(11):2562. doi: 10.3390/nu15112562.
9
Genetic polymorphisms in immune- and inflammation-associated genes and their association with bovine mastitis resistance/susceptibility.免疫和炎症相关基因的遗传多态性及其与奶牛乳腺炎抗性/易感性的关系。
Front Immunol. 2023 Feb 23;14:1082144. doi: 10.3389/fimmu.2023.1082144. eCollection 2023.
10
Ferroptosis in acute kidney injury following crush syndrome: A novel target for treatment.挤压综合征后急性肾损伤中的铁死亡：一种新的治疗靶点。
J Adv Res. 2023 Dec;54:211-222. doi: 10.1016/j.jare.2023.01.016. Epub 2023 Jan 24.
Taurine as a Natural Antioxidant: From Direct Antioxidant Effects to Protective Action in Various Toxicological Models.
牛磺酸作为一种天然抗氧化剂：从直接抗氧化作用到在各种毒理学模型中的保护作用。
Antioxidants (Basel). 2021 Nov 24;10(12):1876. doi: 10.3390/antiox10121876.
4
Taurine protects blood-milk barrier integrity via limiting inflammatory response in Streptococcus uberis infections.牛磺酸通过限制唾液链球菌感染中的炎症反应来保护血乳屏障的完整性。
Int Immunopharmacol. 2021 Dec;101(Pt B):108371. doi: 10.1016/j.intimp.2021.108371. Epub 2021 Nov 15.
5
A Review of the Neutrophil Extracellular Traps (NETs) from Cow, Sheep and Goat Models.牛、绵羊和山羊模型中中性粒细胞胞外陷阱（NETs）的综述。
Int J Mol Sci. 2021 Jul 28;22(15):8046. doi: 10.3390/ijms22158046.
6
Innate Immune Cells and Hypertension: Neutrophils and Neutrophil Extracellular Traps (NETs).固有免疫细胞与高血压：中性粒细胞和中性粒细胞胞外诱捕网（NETs）。
Compr Physiol. 2021 Feb 12;11(1):1575-1589. doi: 10.1002/cphy.c200020.
7
Cl-amidine attenuates lipopolysaccharide-induced mouse mastitis by inhibiting NF-κB, MAPK, NLRP3 signaling pathway and neutrophils extracellular traps release.Cl-脒抑制 NF-κB、MAPK、NLRP3 信号通路和中性粒细胞细胞外诱捕网释放，从而减轻脂多糖诱导的小鼠乳腺炎。
Microb Pathog. 2020 Dec;149:104530. doi: 10.1016/j.micpath.2020.104530. Epub 2020 Sep 24.
8
Taurine chloramine selectively regulates neutrophil degranulation through the inhibition of myeloperoxidase and upregulation of lactoferrin.牛磺酸氯胺通过抑制髓过氧化物酶和上调乳铁蛋白选择性调节中性粒细胞脱粒。
Amino Acids. 2020 Aug;52(8):1191-1199. doi: 10.1007/s00726-020-02886-5. Epub 2020 Aug 31.
9
TLR2 Signaling Pathway Combats Infection by Inducing Mitochondrial Reactive Oxygen Species Production.TLR2 信号通路通过诱导线粒体活性氧产生来抵抗感染。
Cells. 2020 Feb 21;9(2):494. doi: 10.3390/cells9020494.
10
Role of Toll-like receptor 2 against Streptococcus uberis infection in primary mouse mammary epithelial cells.Toll 样受体 2 对抗乳链菌感染的作用：在原代小鼠乳腺上皮细胞中的研究。
Int Immunopharmacol. 2020 Feb;79:106142. doi: 10.1016/j.intimp.2019.106142. Epub 2020 Jan 10.