Grubb B R, Driscoll S M, Bentley P J
Ophthalmic Res. 1987;19(2):101-6. doi: 10.1159/000265480.
Mercury, (Hg2+, using 203Hg2+ as a tracer) was accumulated by the rabbit lens in vitro in a concentration-dependent manner. Saturation levels for the metal ion were greater at higher external concentrations of Hg2+ and exceeded those in the bathing media. Autoradiographic examination showed that the 203Hg was concentrated in the anterior epithelium and lens bow. Release of accumulated 203Hg was enhanced by external Hg2+ and dithiothreitol but was reduced by lanthanum (La3+). Lanthanum also increased net accumulation of Hg2+. The Hg2+ (10(-4) M for 24 h) appeared to be toxic as shown by excessive accumulation of sodium and loss of potassium by the lens in vitro. Mercuric ions appear to leave and enter the lens by diffusion, a process which may involve anionic pathways on its anterior surface where it is principally bound in the anterior epithelial cells.
汞（Hg2+，使用203Hg2+作为示踪剂）在体外可被兔晶状体以浓度依赖的方式积累。在较高的外部Hg2+浓度下，金属离子的饱和水平更高，且超过了浴液中的水平。放射自显影检查显示，203Hg集中在前部上皮和晶状体弓中。外部Hg2+和二硫苏糖醇可增强积累的203Hg的释放，但镧（La3+）可使其释放减少。镧还增加了Hg2+的净积累。如体外实验中晶状体钠的过度积累和钾的流失所示，Hg2+（10(-4) M，处理24小时）似乎具有毒性。汞离子似乎通过扩散进出晶状体，这一过程可能涉及晶状体前表面的阴离子途径，汞主要在前部上皮细胞中与之结合。
