Sirtuin 1 在脑缺血中的作用研究进展。
Research Progress on the Role of Sirtuin 1 in Cerebral Ischemia.
机构信息
School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
School of Life Sciences, Zhejiang Chinese Medical University, Hangzhou, 310051, China.
出版信息
Cell Mol Neurobiol. 2023 Jul;43(5):1769-1783. doi: 10.1007/s10571-022-01288-3. Epub 2022 Sep 24.
Abstract
A significant amount of evidence from the past few years has shown that Sirtuin 1 (SIRT1), a histone deacetylase dinucleotide of nicotinamide adenine dinucleotide (NAD) is closely related to the cerebral ischemia. Several potential neuroprotective strategies like resveratrol, ischemia preconditioning, and caloric restriction exert their neuroprotection effects through SIRT1-related signaling pathway. However, the potential mechanisms and neuroprotection of SIRT1 in the process of cerebral ischemia injury development and recovery have not been systematically elaborated. This review summarized the the deacetylase activity and distribution of SIRT1 as well as analyzed the roles of SIRT1 in astrocytes, microglia, neurons, and brain microvascular endothelial cells (BMECs), and the molecular mechanisms of SIRT1 in cerebral ischemia, providing a theoretical basis for exploration of new therapeutic target in future.
摘要
过去几年的大量证据表明，Sirtuin 1（SIRT1），烟酰胺腺嘌呤二核苷酸（NAD）的组蛋白去乙酰化酶二核苷酸，与脑缺血密切相关。几种潜在的神经保护策略，如白藜芦醇、缺血预处理和热量限制，通过 SIRT1 相关信号通路发挥其神经保护作用。然而，SIRT1 在脑缺血损伤发展和恢复过程中的潜在机制和神经保护作用尚未得到系统阐述。本综述总结了 SIRT1 的去乙酰化酶活性和分布，并分析了 SIRT1 在星形胶质细胞、小胶质细胞、神经元和脑微血管内皮细胞（BMEC）中的作用，以及 SIRT1 在脑缺血中的分子机制，为未来探索新的治疗靶点提供了理论基础。
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