He Shaoping, Bian Guozhi, Guo Yuming, Guo Jiyu
College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Animal Husbandry and Fisheries Research Center of Guangdong Haid Group Co., Ltd., Guangzhou 511400, China.
Animals (Basel). 2024 Sep 5;14(17):2585. doi: 10.3390/ani14172585.
To investigate the possible protective effect of hesperidin on intestinal damage caused by high-temperature heat stress in yellow-feathered broilers, 960 broilers aged 21 days were randomly divided into four groups: HT, HT300, HT450, and HT600, with each group receiving different amounts of hesperidin supplementation (0, 300, 450, and 600 mg/kg). The dietary supplementation of hesperidin could mitigate the elevation of corticosterone (CORT) and adrenocorticotropic hormone (ATCH) levels in serum from yellow-feathered broilers induced by heat stress. The supplementation of 300 mg/kg and 450 mg/kg of hesperidin reduced crypt depth and increased the V/C ratio in the small intestine compared to the HT group. The dietary supplementation of hesperidin decreased endotoxin and D-lactic acid levels in the blood, and dietary supplementation of 300 mg/kg of hesperidin increased the expression of and mRNA in the jejunum compared with the HT group. Furthermore, the dietary supplementation of 300 mg/kg of hesperidin decreased serum IL-1β and IL-6 levels. In comparison, supplementation with 300 mg/kg and 450 mg/kg of hesperidin decreased serum TNF-α levels in yellow-feathered broilers compared to the HT group. Moreover, the dietary supplementation of hesperidin decreased mRNA levels. Overall, these data suggest that dietary supplementation with hesperidin potentially improves intestinal injury caused by heat stress in yellow-feathered broilers.
为研究橙皮苷对高温热应激引起的黄羽肉鸡肠道损伤的可能保护作用，将960只21日龄的肉鸡随机分为四组：HT组、HT300组、HT450组和HT600组，每组给予不同剂量的橙皮苷补充剂（0、300、450和600 mg/kg）。日粮中添加橙皮苷可减轻热应激诱导的黄羽肉鸡血清中皮质酮（CORT）和促肾上腺皮质激素（ATCH）水平的升高。与HT组相比，添加300 mg/kg和450 mg/kg橙皮苷可降低小肠隐窝深度并增加V/C比值。日粮中添加橙皮苷可降低血液中内毒素和D-乳酸水平，与HT组相比，添加300 mg/kg橙皮苷可增加空肠中 和 mRNA的表达。此外，添加300 mg/kg橙皮苷可降低血清IL-1β和IL-6水平。相比之下，与HT组相比，添加300 mg/kg和450 mg/kg橙皮苷可降低黄羽肉鸡血清TNF-α水平。此外，日粮中添加橙皮苷可降低 mRNA水平。总体而言，这些数据表明，日粮中添加橙皮苷可能改善黄羽肉鸡热应激引起的肠道损伤。
