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Targeting glutamine metabolism enhances responses to platinum-based chemotherapy in triple-negative breast cancers (TNBC).

作者信息

Hong Jiaxin, Shen Yao-An, Hsu Chih-Yi, Huang Peng, Tomaszewski Alicja, Gabrielson Edward, Shih Ie-Ming, Gaillard Stephanie, Wang Tian-Li

机构信息

Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Baltimore, MD 21231, USA.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

出版信息

Genes Dis. 2022 Mar 21;9(6):1408-1411. doi: 10.1016/j.gendis.2022.02.009. eCollection 2022 Nov.

DOI:10.1016/j.gendis.2022.02.009
PMID:36157486
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9485268/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3749/9485268/ac5619e8cbb2/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3749/9485268/ac5619e8cbb2/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3749/9485268/ac5619e8cbb2/gr1.jpg

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Inhibition of the MYC-Regulated Glutaminase Metabolic Axis Is an Effective Synthetic Lethal Approach for Treating Chemoresistant Ovarian Cancers.抑制 MYC 调控的谷氨酰胺酶代谢轴是治疗化疗耐药卵巢癌的有效合成致死方法。
Cancer Res. 2020 Oct 15;80(20):4514-4526. doi: 10.1158/0008-5472.CAN-19-3971. Epub 2020 Aug 28.
2
Carboplatin in BRCA1/2-mutated and triple-negative breast cancer BRCAness subgroups: the TNT Trial.BRCA1/2 突变型和三阴性乳腺癌 BRCA 样亚组中的卡铂：TNT 试验。
Nat Med. 2018 May;24(5):628-637. doi: 10.1038/s41591-018-0009-7. Epub 2018 Apr 30.
3
From Krebs to clinic: glutamine metabolism to cancer therapy.
谷氨酸通过IRE1α/XBP1介导的巨噬细胞极化促进三阴性乳腺癌发展：机制洞察与治疗
Discov Oncol. 2025 Jun 5;16(1):1009. doi: 10.1007/s12672-025-02790-y.
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Mitochondrial inhibitors: a new horizon in breast cancer therapy.线粒体抑制剂：乳腺癌治疗的新视野。
Front Pharmacol. 2024 Jul 4;15:1421905. doi: 10.3389/fphar.2024.1421905. eCollection 2024.
5
Exploiting the Achilles' heel of cancer: disrupting glutamine metabolism for effective cancer treatment.利用癌症的阿喀琉斯之踵：破坏谷氨酰胺代谢以实现有效的癌症治疗。
Front Pharmacol. 2024 Mar 6;15:1345522. doi: 10.3389/fphar.2024.1345522. eCollection 2024.
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Targeting cancer metabolic pathways for improving chemotherapy and immunotherapy.针对癌症代谢途径以改善化疗和免疫疗法。
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Integrating single-cell RNA-seq and bulk RNA-seq to construct prognostic signatures to explore the role of glutamine metabolism in breast cancer.整合单细胞 RNA-seq 和 bulk RNA-seq 构建预后标志物，探索谷氨酰胺代谢在乳腺癌中的作用。
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