Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Graduate School of China Academy of Chinese Medical Sciences, Beijing, China.
Front Public Health. 2022 Sep 9;10:966093. doi: 10.3389/fpubh.2022.966093. eCollection 2022.
High body mass index (BMI) plays a critical role in the initiation and development of type 2 diabetes (T2D). Up to now, far too little attention has been paid to the global burden of T2D attributable to high BMI. This study aims to report the deaths and disability-adjusted life years (DALYs) of T2D related to high BMI in 204 countries and territories from 1990 to 2019.
Data on T2D burden attributable to high BMI were retrieved from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. The global cases, age-standardized rates of mortality (ASMR), and disability-adjusted life years (ASDR) attributable to high BMI were estimated by age, sex, geographical location, and socio-demographic index (SDI). The estimated annual percentage change (EAPC) was calculated to quantify the trends of ASMR and ASDR during the period 1990-2019.
Globally, there were 619,494.8 deaths and 34,422,224.8 DALYs of T2D attributed to high BMI in 2019, more than triple in 1990. Moreover, the pace of increase in ASMR and ASDR accelerated during 1990-2019, with EAPC of 1.36 (95% CI: 1.27 to 1.45) and 2.13 (95% CI: 2.10 to 2.17) separately, especially in men, South Asia, and low-middle SDI regions. Oceania was the high-risk area of standardized T2D deaths and DALYs attributable to high BMI in 2019, among which Fiji was the country with the heaviest burden. In terms of SDI, middle SDI regions had the biggest T2D-related ASMR and ASDR in 2019.
The global deaths and DALYs of T2D attributable to high BMI substantially increased from 1990 to 2019. High BMI as a major public health problem needs to be tackled properly and timely in patients with T2D.
高身体质量指数（BMI）在 2 型糖尿病（T2D）的发生和发展中起着关键作用。到目前为止，人们对高 BMI 导致的 T2D 的全球负担关注甚少。本研究旨在报告 204 个国家和地区 1990 年至 2019 年高 BMI 相关 T2D 的死亡人数和伤残调整生命年（DALY）。
从全球疾病、伤害和危险因素研究（GBD）2019 中检索到与高 BMI 相关的 T2D 负担数据。通过年龄、性别、地理位置和社会人口指数（SDI）来估计高 BMI 归因于 T2D 的全球病例数、标准化死亡率（ASMR）和伤残调整生命年（ASDR）。计算估计的年变化百分比（EAPC），以量化 1990 年至 2019 年期间 ASMR 和 ASDR 的趋势。
全球范围内，2019 年有 619494.8 例 T2D 死亡和 34422248.8 例 DALY 归因于高 BMI，是 1990 年的三倍多。此外，1990-2019 年期间 ASMR 和 ASDR 的增长速度加快，EAPC 分别为 1.36（95%CI：1.27-1.45）和 2.13（95%CI：2.10-2.17），尤其是在男性、南亚和中低 SDI 地区。2019 年，大洋洲是高 BMI 归因于标准化 T2D 死亡和 DALY 的高风险地区，其中斐济的负担最重。就 SDI 而言，2019 年中 SDI 地区 T2D 相关 ASMR 和 ASDR 最大。
全球范围内，高 BMI 导致的 T2D 死亡人数和 DALY 从 1990 年到 2019 年大幅增加。高 BMI 作为一个主要的公共卫生问题，需要在 T2D 患者中得到及时妥善的处理。
