Yang Shiming, Zhou Licheng, Gong Wanchen, Guo Bin, Wang Linfeng
Department of Orthopedics, Nanping First Hospital Affiliated to Fujian Medical University, Nanping, Fujian, China.
Arch Med Sci. 2024 Apr 28;20(6):1841-1853. doi: 10.5114/aoms/187150. eCollection 2024.
The aim was to examine data from the Global Burden of Disease Study (GBD) 2019 to determine the global burden of osteoarthritis (OA) from 1990 to 2019 that is attributable to high body mass index (BMI).
Disability-adjusted life years (DALYs) and age-standardized DALY rates, and their corresponding estimated annual percentage changes (EAPCs), were used to compare estimated OA burdens between countries and regions. Moreover, a comparative risk assessment framework was used to estimate the risks attributable to high BMI in terms of DALYs.
From 1990 to 2019, the age-standardized DALY rate for OA attributable to high BMI increased significantly (EAPC = 1.45, 95% CI: 1.44-1.47). Moreover, from 1990 to 2019, the age-standardized DALY rate and number of DALYs for OA attributable to high BMI increased less in women than in men. From 1990 to 2019, the age-standardized DALY rate for OA attributable to high BMI increased the most in South Asia (EAPC = 3.94). From 1990 to 2019, among 204 countries worldwide, the age-standardized DALY rate for OA attributable to high BMI increased the most in Equatorial Guinea (EAPC = 7.42). Also, the burden was higher in high-sociodemographic index (SDI) regions than in low-SDI regions.
The global burden of OA attributable to high BMI increased significantly from 1990 to 2019. In particular, this burden was higher in women than in men; primarily affected middle-aged and older adults; and was generally greater in high-SDI regions than in low-SDI regions.
目的是研究全球疾病负担研究（GBD）2019的数据，以确定1990年至2019年因高体重指数（BMI）导致的全球骨关节炎（OA）负担。
使用伤残调整生命年（DALYs）和年龄标准化DALY率及其相应的估计年百分比变化（EAPCs）来比较国家和地区之间估计的OA负担。此外，采用比较风险评估框架，根据DALYs估计高BMI所致风险。
1990年至2019年，因高BMI导致的OA年龄标准化DALY率显著上升（EAPC = 1.45，95% CI：1.44 - 1.47）。此外，1990年至2019年，因高BMI导致的OA年龄标准化DALY率和DALYs数量在女性中的增幅小于男性。1990年至2019年，因高BMI导致的OA年龄标准化DALY率在南亚上升幅度最大（EAPC = 3.94）。1990年至2019年，在全球204个国家中，因高BMI导致的OA年龄标准化DALY率在赤道几内亚上升幅度最大（EAPC = 7.42）。此外，社会人口统计学指数（SDI）高的地区负担高于SDI低的地区。
1990年至2019年，因高BMI导致的全球OA负担显著增加。特别是，女性负担高于男性；主要影响中年及老年人；且SDI高的地区总体负担通常高于SDI低的地区。
