Gong Fengying, Qu Rongmei, Li Yongchun, Lv Ying, Dai Jingxing
Department of Traditional Chinese Medicine, Nanfang Hospital of Southern Medical University, Guangzhou, China.
Guangdong Provincial Key Laboratory of Medical Biomechanics and Guangdong Engineering Research Center for Translation of Medical 3D Printing Application and National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
Front Pharmacol. 2022 Sep 7;13:976561. doi: 10.3389/fphar.2022.976561. eCollection 2022.
Fibrosis-related diseases (FRD) include cerebral fibrosis, pulmonary fibrosis, cardiac fibrosis, liver fibrosis, renal fibrosis, peritoneal fibrosis, etc. The effects of fibrosis can be severe, resulting in organ dysfunction, functional decline, and even organ failure, which can cause serious health problems. Currently, there is no effective modern medicine for anti-fibrosis in the clinics; however, Chinese medicine has a certain beneficial effect on treating such diseases. (AM) has rich medicinal value, and its anti-fibrosis effect has been recently investigated. In recent years, more and more experimental studies have been conducted on the intervention of astragaloside IV (AS-IV), astragalus polysaccharide (APS), astragalus flavone, cycloastragalus alcohol, astragalus water extract and other pharmacological components in fibrosis-related diseases, attracting the interest of researchers. We aim to provide ideas for future research by summarizing recent research advances of AM in treating fibrosis-related diseases. A literature search was conducted from the core collections of electronic databases such as Baidu Literature, Sciencen.com, Google Scholar, PubMed, and Science Direct using the above keywords and the pharmacological and phytochemical details of the plant. AM can be used to intervene in fibrosis-disease progression by regulating inflammation, oxidative stress, the immune system, and metabolism. AS-IV, APS, and astragalus flavone were studied and discussed in detail. These components have high potential anti-fibrosis activity. Overall, this review aims to gain insight into the AM's role in treating fibro-related diseases.
纤维化相关疾病（FRD）包括脑纤维化、肺纤维化、心脏纤维化、肝纤维化、肾纤维化、腹膜纤维化等。纤维化的影响可能很严重，会导致器官功能障碍、功能衰退，甚至器官衰竭，从而引发严重的健康问题。目前，临床上尚无有效的抗纤维化现代医学药物；然而，中药在治疗此类疾病方面具有一定的有益作用。黄芪具有丰富的药用价值，其抗纤维化作用最近受到了研究。近年来，越来越多的实验研究针对黄芪甲苷（AS-IV）、黄芪多糖（APS）、黄芪黄酮、环黄芪醇、黄芪水提取物等药理成分对纤维化相关疾病的干预作用展开，吸引了研究人员的关注。我们旨在通过总结黄芪在治疗纤维化相关疾病方面的最新研究进展，为未来的研究提供思路。使用上述关键词以及该植物的药理和植物化学细节，在百度文献、Sciencen.com、谷歌学术、PubMed和Science Direct等电子数据库的核心馆藏中进行了文献检索。黄芪可通过调节炎症、氧化应激、免疫系统和代谢来干预纤维化疾病的进展。对AS-IV、APS和黄芪黄酮进行了详细研究和讨论。这些成分具有很高的潜在抗纤维化活性。总体而言，本综述旨在深入了解黄芪在治疗纤维化相关疾病中的作用。
