Münz Christian
Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Switzerland.
Semin Immunol. 2022 Mar;60:101652. doi: 10.1016/j.smim.2022.101652. Epub 2022 Sep 23.
The two γ-herpesviruses Epstein Barr virus (EBV) and Kaposi sarcoma associated herpesvirus (KSHV) are each associated with more than 1% of all tumors in humans. While EBV establishes persistent infection in nearly all adult individuals, KSHV benefits from this widespread EBV prevalence for its own persistence. Interestingly, EBV infection expands early differentiated NKG2AKIR NK cells that protect against lytic EBV infection, while KSHV co-infection drives accumulation of poorly functional CD56CD16 NK cells. Thus persistent γ-herpesvirus infections are sculptors of human NK cell repertoires and the respectively stimulated NK cell subsets should be considered for immunotherapies of EBV and KSHV associated malignancies.
两种γ疱疹病毒，即爱泼斯坦-巴尔病毒（EBV）和卡波西肉瘤相关疱疹病毒（KSHV），在人类所有肿瘤中所占比例均超过1%。EBV几乎在所有成年人中建立持续感染，而KSHV因其自身的持续存在而受益于EBV的广泛流行。有趣的是，EBV感染可扩增早期分化的NKG2A+KIR NK细胞，这些细胞可抵御EBV的裂解性感染，而KSHV共感染则促使功能不良的CD56+CD16 NK细胞积累。因此，持续性γ疱疹病毒感染是人类NK细胞库的塑造者，在针对EBV和KSHV相关恶性肿瘤的免疫治疗中应考虑分别受到刺激的NK细胞亚群。
