Institute of Aquatic Science and Technology, National Kaohsiung University of Science and Technology, Kaohsiung City 81157, Taiwan; Centre for Energy and Environmental Sustainability, Lucknow 226 029, Uttar Pradesh, India.
Institute of Aquatic Science and Technology, National Kaohsiung University of Science and Technology, Kaohsiung City 81157, Taiwan; Sustainable Environment Research Centre, National Kaohsiung University of Science and Technology, Kaohsiung City 81157, Taiwan; Department of Marine Environmental Engineering, National Kaohsiung University of Science and Technology, Kaohsiung City, Taiwan.
Bioresour Technol. 2022 Nov;364:128030. doi: 10.1016/j.biortech.2022.128030. Epub 2022 Sep 26.
Microalgae have emerged as the best source of high-value astaxanthin producers. Algal astaxanthin possesses numerous bioactivities hence the rising demand for several health applications and is broadly used in pharmaceuticals, aquaculture, health foods, cosmetics, etc. Among several low-priced synthetic astaxanthin, natural astaxanthin is still irreplaceable for human consumption and food-additive uses. This review highlights the recent development in production enhancement and cost-effective extraction techniques that may apply to large-scale astaxanthin biorefinery. Primarily, the biosynthetic pathway of astaxanthin is elaborated with the key enzymes involved in the metabolic process. Moreover, discussed the latest astaxanthin enhancement strategies mainly including chemicals as product inducers and byproducts inhibitors. Later, various physical, chemical, and biological cell disruption methods are compared for cell disruption efficiency, and astaxanthin extractability. The aim of this review is to provide a comprehensive review of advancements in astaxanthin research covering scalable upstream and downstream astaxanthin bioproduction aspects.
微藻已成为生产高附加值虾青素的最佳原料。藻源虾青素具有多种生物活性，因此对其在多个健康应用领域的需求不断增加，广泛应用于制药、水产养殖、保健品、化妆品等领域。与几种低价的合成虾青素相比，天然虾青素仍然是人类消费和食品添加剂用途不可替代的。本文综述了生产强化和具有成本效益的提取技术的最新进展，这些技术可能适用于大规模虾青素生物炼制。首先，详细阐述了虾青素的生物合成途径以及参与代谢过程的关键酶。此外，还讨论了最新的虾青素强化策略，主要包括作为产物诱导剂和副产物抑制剂的化学品。随后，比较了各种物理、化学和生物细胞破碎方法的细胞破碎效率和虾青素提取率。本文的目的是提供对虾青素研究进展的全面综述，涵盖可扩展的上游和下游虾青素生物生产方面。
