Yin Jinbao, Li Dingxin, Zheng Tianming, Wang Xun, Hu Bin, Wang Peifang
Key Laboratory of Integrated Regulation and Resources Development on Shallow Lakes of Ministry of Education, College of Environment, Hohai University, Nanjing, China.
State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, China.
Front Microbiol. 2022 Sep 13;13:991818. doi: 10.3389/fmicb.2022.991818. eCollection 2022.
Halonitromethanes (HNMs) as one typical class of nitrogenous disinfection byproducts (DBPs) have been widely found in drinking water and are receiving more and more attentions because of their high cytotoxicity, genotoxicity, and developmental toxicity. However, the effects of HNMs exposure on the intestinal tract and intestinal flora remain unknown. This study comprehensively determined the effects of trichloronitromethane, bromonitromethane, and bromochloronitromethane exposure on the intestinal tract and intestinal flora. Results showed that the three HNMs induced intestinal oxidative stress and inflammatory response. Further, HNMs exposure could change the diversities and community structure of intestinal flora, thereby triggering intestinal flora dysbiosis, which might be associated with the intestinal damage such as oxidative stress and inflammation. The intestinal flora dysbiosis was accompanied with mark alterations in function of intestinal flora, such as carbohydrate, lipid, and amino acid metabolisms. This research provides a new insight into studying the toxicity of HNMs exposure based on intestinal flora, which will further improve the health risk assessment of DBPs in drinking water.
卤代硝基甲烷（HNMs）作为一类典型的含氮消毒副产物（DBPs），已在饮用水中被广泛发现，并且由于其具有高细胞毒性、遗传毒性和发育毒性而受到越来越多的关注。然而，HNMs暴露对肠道和肠道菌群的影响仍然未知。本研究全面测定了三氯硝基甲烷、溴硝基甲烷和溴氯硝基甲烷暴露对肠道和肠道菌群的影响。结果表明，这三种HNMs均诱导了肠道氧化应激和炎症反应。此外，HNMs暴露可改变肠道菌群的多样性和群落结构，从而引发肠道菌群失调，这可能与氧化应激和炎症等肠道损伤有关。肠道菌群失调伴随着肠道菌群功能的显著改变，如碳水化合物、脂质和氨基酸代谢。本研究为基于肠道菌群研究HNMs暴露的毒性提供了新的见解，这将进一步完善饮用水中DBPs的健康风险评估。
