State Key Laboratory of Crop Stress Biology for Arid areas, College of Plant Protection, Northwest A&F University, Yangling, Shaanxi 712100, China.
State Key Laboratory of Crop Stress Biology for Arid areas, College of Plant Protection, Northwest A&F University, Yangling, Shaanxi 712100, China.
Int J Biol Macromol. 2022 Dec 1;222(Pt A):1007-1014. doi: 10.1016/j.ijbiomac.2022.09.211. Epub 2022 Sep 28.
Fusarium is a large genus of filamentous fungi including numerous important plant pathogens. In addition to causing huge economic losses of crops, some Fusarium species produce a wide range of mycotoxins in cereal crops that affect human and animal health. The intracellular signaling in Fusarium plays an important role in growth, sexual and asexual developments, pathogenesis, and mycotoxin biosynthesis. In this review, we highlight the recent advances and provide insight into signal sensing and transduction in Fusarium species. G protein-coupled receptors and other conserved membrane receptors mediate recognition of environmental cues and activate complex intracellular signaling. Once activated, the cAMP-PKA and three well-conserved MAP kinase pathways activate downstream transcriptional regulatory networks. The functions of individual signaling pathways have been well characterized in a variety of Fusarium species, showing the conserved components with diverged functions. Furthermore, these signaling pathways crosstalk and coordinately regulate various fungal developments and infection-related morphogenesis.
镰刀菌是一个大型丝状真菌属，包括许多重要的植物病原菌。除了对农作物造成巨大的经济损失外，一些镰刀菌物种还会在谷物中产生广泛的霉菌毒素，影响人类和动物的健康。镰刀菌中的细胞内信号转导在生长、有性和无性发育、发病机制和霉菌毒素生物合成中起着重要作用。在这篇综述中，我们强调了最新的进展，并深入了解了镰刀菌属中的信号感知和转导。G 蛋白偶联受体和其他保守的膜受体介导对环境线索的识别，并激活复杂的细胞内信号转导。一旦被激活，cAMP-PKA 和三个保守的 MAP 激酶途径就会激活下游的转录调控网络。在各种镰刀菌物种中，单个信号通路的功能已经得到了很好的描述，显示出具有不同功能的保守成分。此外，这些信号通路相互作用，并协调调节各种真菌发育和与感染相关的形态发生。
