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丹麦关注的 SARS-CoV-2 奥密克戎变体 BA.1 和 BA.2 亚变体的家庭传播。

Household transmission of SARS-CoV-2 Omicron variant of concern subvariants BA.1 and BA.2 in Denmark.

机构信息

Department of Economics & Center for Economic Behavior and Inequality, University of Copenhagen, Copenhagen, Denmark.

Danish Ministry of Health, Copenhagen, Denmark.

出版信息

Nat Commun. 2022 Sep 30;13(1):5760. doi: 10.1038/s41467-022-33498-0.


DOI:10.1038/s41467-022-33498-0
PMID:36180438
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9524324/
Abstract

SARS coronavirus 2 (SARS-CoV-2) continues to evolve and new variants emerge. Using nationwide Danish data, we estimate the transmission dynamics of SARS-CoV-2 Omicron subvariants BA.1 and BA.2 within households. Among 22,678 primary cases, we identified 17,319 secondary infections among 50,588 household contacts during a 1-7 day follow-up. The secondary attack rate (SAR) was 29% and 39% in households infected with Omicron BA.1 and BA.2, respectively. BA.2 was associated with increased susceptibility of infection for unvaccinated household contacts (Odds Ratio (OR) 1.99; 95%-CI 1.72-2.31), fully vaccinated contacts (OR 2.26; 95%-CI 1.95-2.62) and booster-vaccinated contacts (OR 2.65; 95%-CI 2.29-3.08), compared to BA.1. We also found increased infectiousness from unvaccinated primary cases infected with BA.2 compared to BA.1 (OR 2.47; 95%-CI 2.15-2.84), but not for fully vaccinated (OR 0.66; 95%-CI 0.57-0.78) or booster-vaccinated primary cases (OR 0.69; 95%-CI 0.59-0.82). Omicron BA.2 is inherently more transmissible than BA.1. Its immune-evasive properties also reduce the protective effect of vaccination against infection, but do not increase infectiousness of breakthrough infections from vaccinated individuals.

摘要

SARS 冠状病毒 2 (SARS-CoV-2) 持续进化,新的变体不断出现。我们利用丹麦全国范围内的数据,估计了 SARS-CoV-2 奥密克戎变异株 BA.1 和 BA.2 在家庭内的传播动态。在 22678 例原发性病例中,我们在 1-7 天的随访期间,在 50588 名家庭接触者中发现了 17319 例继发性感染。家庭中感染奥密克戎 BA.1 和 BA.2 的继发性攻击率(SAR)分别为 29%和 39%。未接种疫苗的家庭接触者(优势比(OR)1.99;95%CI 1.72-2.31)、完全接种疫苗的接触者(OR 2.26;95%CI 1.95-2.62)和加强针接种者(OR 2.65;95%CI 2.29-3.08)感染的易感性增加,与 BA.1 相比。我们还发现,与 BA.1 相比,未接种疫苗的原发性病例感染 BA.2 时的传染性增加(OR 2.47;95%CI 2.15-2.84),但完全接种疫苗的病例(OR 0.66;95%CI 0.57-0.78)或加强针接种的病例(OR 0.69;95%CI 0.59-0.82)则不然。奥密克戎 BA.2 比 BA.1 固有地更具传染性。它的免疫逃避特性也降低了疫苗对感染的保护作用,但不会增加接种者突破性感染的传染性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5c6/9525717/e96669e69896/41467_2022_33498_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5c6/9525717/e96669e69896/41467_2022_33498_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5c6/9525717/e96669e69896/41467_2022_33498_Fig1_HTML.jpg

相似文献

[1]
Household transmission of SARS-CoV-2 Omicron variant of concern subvariants BA.1 and BA.2 in Denmark.

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World J Virol. 2025-6-25

[2]
One-Year Monitoring of the Evolution of SARS-CoV-2 Omicron Subvariants Through Wastewater Analysis (Central Italy, August 2023-July 2024).

Life (Basel). 2025-5-24

[3]
Pathogenesis and transmission of SARS-CoV-2 D614G, Alpha, Gamma, Delta, and Omicron variants in golden hamsters.

Npj Viruses. 2025-2-24

[4]
Skin patch delivery of a SARS-CoV-2 spike DNA vaccine produces broad neutralising antibody responses.

Heliyon. 2025-2-7

[5]
Genomic Epidemiology of the Main SARS-CoV-2 Variants Circulating in Italy During the Omicron Era.

J Med Virol. 2025-2

[6]
The changing demographics and severity in hospitalized patients across COVID-19 variants: A national cohort study.

J Clin Transl Sci. 2025-1-6

[7]
SARS-CoV-2 evolution on a dynamic immune landscape.

Nature. 2025-3

[8]
Next generation sequencing of multiple SARS-CoV-2 infections in the Omicron Era.

Sci Rep. 2025-1-27

[9]
SARS-CoV-2 Nsp6-Omicron causes less damage to the Drosophila heart and mouse cardiomyocytes than ancestral Nsp6.

Commun Biol. 2024-12-3

[10]
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Eur J Radiol Open. 2024-10-17

本文引用的文献

[1]
Longitudinal Analysis of SARS-CoV-2 Vaccine Breakthrough Infections Reveals Limited Infectious Virus Shedding and Restricted Tissue Distribution.

Open Forum Infect Dis. 2022-4-13

[2]
Transmission and Infectious SARS-CoV-2 Shedding Kinetics in Vaccinated and Unvaccinated Individuals.

JAMA Netw Open. 2022-5-2

[3]
SARS-CoV-2 Delta Variant in Jingmen City, Hubei Province, China, 2021: Children Susceptible and Vaccination Breakthrough Infection.

Front Microbiol. 2022-4-13

[4]
Genomic, immunological, and clinical analysis of COVID-19 vaccine breakthrough infections in Beijing, China.

J Med Virol. 2022-5

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Early assessment of the clinical severity of the SARS-CoV-2 omicron variant in South Africa: a data linkage study.

Lancet. 2022-1-29

[6]
Considerable escape of SARS-CoV-2 Omicron to antibody neutralization.

Nature. 2022-2

[7]
Mutational and phylogenetic analyses of the two lineages of the Omicron variant.

J Med Virol. 2022-5

[8]
SARS-CoV-2 Omicron strain exhibits potent capabilities for immune evasion and viral entrance.

Signal Transduct Target Ther. 2021-12-17

[9]
Effect of a nationwide booster vaccine rollout in Israel on SARS-CoV-2 infection and severe illness in young adults.

Travel Med Infect Dis. 2021

[10]
Tracking the international spread of SARS-CoV-2 lineages B.1.1.7 and B.1.351/501Y-V2 with grinch.

Wellcome Open Res. 2021-9-17

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