Department of Economics & Center for Economic Behavior and Inequality, University of Copenhagen, Copenhagen, Denmark.
Danish Ministry of Health, Copenhagen, Denmark.
Nat Commun. 2022 Sep 30;13(1):5760. doi: 10.1038/s41467-022-33498-0.
SARS coronavirus 2 (SARS-CoV-2) continues to evolve and new variants emerge. Using nationwide Danish data, we estimate the transmission dynamics of SARS-CoV-2 Omicron subvariants BA.1 and BA.2 within households. Among 22,678 primary cases, we identified 17,319 secondary infections among 50,588 household contacts during a 1-7 day follow-up. The secondary attack rate (SAR) was 29% and 39% in households infected with Omicron BA.1 and BA.2, respectively. BA.2 was associated with increased susceptibility of infection for unvaccinated household contacts (Odds Ratio (OR) 1.99; 95%-CI 1.72-2.31), fully vaccinated contacts (OR 2.26; 95%-CI 1.95-2.62) and booster-vaccinated contacts (OR 2.65; 95%-CI 2.29-3.08), compared to BA.1. We also found increased infectiousness from unvaccinated primary cases infected with BA.2 compared to BA.1 (OR 2.47; 95%-CI 2.15-2.84), but not for fully vaccinated (OR 0.66; 95%-CI 0.57-0.78) or booster-vaccinated primary cases (OR 0.69; 95%-CI 0.59-0.82). Omicron BA.2 is inherently more transmissible than BA.1. Its immune-evasive properties also reduce the protective effect of vaccination against infection, but do not increase infectiousness of breakthrough infections from vaccinated individuals.
SARS 冠状病毒 2 (SARS-CoV-2) 持续进化,新的变体不断出现。我们利用丹麦全国范围内的数据,估计了 SARS-CoV-2 奥密克戎变异株 BA.1 和 BA.2 在家庭内的传播动态。在 22678 例原发性病例中,我们在 1-7 天的随访期间,在 50588 名家庭接触者中发现了 17319 例继发性感染。家庭中感染奥密克戎 BA.1 和 BA.2 的继发性攻击率(SAR)分别为 29%和 39%。未接种疫苗的家庭接触者(优势比(OR)1.99;95%CI 1.72-2.31)、完全接种疫苗的接触者(OR 2.26;95%CI 1.95-2.62)和加强针接种者(OR 2.65;95%CI 2.29-3.08)感染的易感性增加,与 BA.1 相比。我们还发现,与 BA.1 相比,未接种疫苗的原发性病例感染 BA.2 时的传染性增加(OR 2.47;95%CI 2.15-2.84),但完全接种疫苗的病例(OR 0.66;95%CI 0.57-0.78)或加强针接种的病例(OR 0.69;95%CI 0.59-0.82)则不然。奥密克戎 BA.2 比 BA.1 固有地更具传染性。它的免疫逃避特性也降低了疫苗对感染的保护作用,但不会增加接种者突破性感染的传染性。
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