Centre for Epidemiology Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, University of Manchester, Manchester, United Kingdom; Academic Rheumatology, School of Medicine, University of Nottingham, Nottingham, United Kingdom.
School of Health Sciences, University of Nottingham, Nottingham, United Kingdom.
Semin Arthritis Rheum. 2022 Dec;57:152101. doi: 10.1016/j.semarthrit.2022.152101. Epub 2022 Sep 24.
To develop evidence-based expert recommendations for non-pharmacological treatments for pain, fatigue, sleep problems, and depression in fibromyalgia.
An international, multidisciplinary Delphi exercise was conducted. Authors of EULAR and the Canadian Fibromyalgia Guidelines Group, members of the American Pain Society and clinicians with expertise in fibromyalgia were invited. Participants were asked to select non-pharmacological interventions that could be offered for specific fibromyalgia symptoms and to classify them as either core or adjunctive treatments. An evidence summary was provided to aid the decision making. Items receiving >70% votes were accepted, those receiving <30% votes were rejected and those obtaining 30-70% votes were recirculated for up to two additional rounds.
Seventeen experts participated (Europe (n = 10), North America (n = 6), and Israel (n = 1)) in the Delphi exercise and completed all three rounds. Aerobic exercise, education, sleep hygiene and cognitive behavioural therapy were recommended as core treatments for all symptoms. Mind-body exercises were recommended as core interventions for pain, fatigue and sleep problems. Mindfulness was voted core treatment for depression, and adjunctive treatment for other symptoms. Other interventions, namely music, relaxation, hot bath, and local heat were voted as adjunctive treatments, varying between symptoms.
This study provided evidence-based expert consensus recommendations on non-pharmacological treatments for fibromyalgia that may be used to individualise treatments in clinical practice targeting the diverse symptoms associated with fibromyalgia.
为纤维肌痛症的疼痛、疲劳、睡眠问题和抑郁等症状制定基于循证医学的非药物治疗专家建议。
开展了一项国际性的多学科德尔菲法研究。邀请了 EULAR 和加拿大纤维肌痛症指南小组的作者、美国疼痛学会的成员以及具有纤维肌痛症专业知识的临床医生参与。参与者被要求选择可用于特定纤维肌痛症症状的非药物干预措施,并将其归类为核心或辅助治疗。提供了证据总结以辅助决策。获得>70%票数的项目被接受,获得<30%票数的项目被拒绝,获得 30-70%票数的项目进行了最多两轮的重新投票。
17 名专家(欧洲 10 名、北美 6 名和以色列 1 名)参与了德尔菲法研究并完成了所有三轮投票。有氧运动、教育、睡眠卫生和认知行为疗法被推荐为所有症状的核心治疗方法。身心锻炼被推荐为疼痛、疲劳和睡眠问题的核心干预措施。正念被选为治疗抑郁的核心治疗方法,也是其他症状的辅助治疗方法。其他干预措施,如音乐、放松、热水浴和局部热疗,被投票为辅助治疗方法,适用于不同的症状。
本研究为纤维肌痛症的非药物治疗提供了基于循证医学的专家共识建议,可用于临床实践中针对纤维肌痛症相关的各种症状进行个体化治疗。