Lan Tianming, Li Haimeng, Yang Shangchen, Shi Minhui, Han Lei, Sahu Sunil Kumar, Lu Yaxian, Wang Jiangang, Zhou Mengchao, Liu Hui, Huang Junxuan, Wang Qing, Zhu Yixin, Wang Li, Xu Yanchun, Lin Chuyu, Liu Huan, Hou Zhijun
BGI Life Science Joint Research Center, Northeast Forestry University, Harbin 150040, China.
State Key Laboratory of Agricultural Genomics, BGI-Shenzhen, Shenzhen 518083, China.
iScience. 2022 Sep 15;25(10):105117. doi: 10.1016/j.isci.2022.105117. eCollection 2022 Oct 21.
The raccoon dog () is an invasive canid species native to East Asia with several distinct characteristics. Here, we report a chromosome-scale genome of the raccoon dog with high contiguity, completeness, and accuracy. The intact taste receptor genes, expanded gene families, and positively selected genes related to digestion, absorption, foraging, and detoxification likely support the omnivory of raccoon dogs. Several positively selected genes and raccoon dog-specific mutations in and genes may explain their high reproductivity. Enriched GO terms in energy metabolism and positively selected immune genes were speculated to be closely related to the diverse immune system of raccoon dogs. In addition, we found that several expanded gene families and positively selected genes related to lipid metabolism and insulin resistance may contribute to winter sleep of the raccoon dog. This high-quality genome provides a valuable resource for understanding the evolutionary characteristics of this species.
貉是一种原产于东亚的入侵性犬科物种，具有几个明显的特征。在此，我们报告了一个具有高连续性、完整性和准确性的貉染色体水平基因组。完整的味觉受体基因、扩张的基因家族以及与消化、吸收、觅食和解毒相关的正选择基因可能支持了貉的杂食性。几个正选择基因以及某些基因中的貉特异性突变可能解释了它们的高繁殖力。能量代谢中富集的基因本体（GO）术语和正选择的免疫基因据推测与貉多样的免疫系统密切相关。此外，我们发现几个与脂质代谢和胰岛素抵抗相关的扩张基因家族和正选择基因可能促成了貉的冬眠。这个高质量的基因组为理解该物种的进化特征提供了宝贵资源。
