Li Rui, Li Qi, Chu Xiaolei, Li Lan, Li Xiaoyi, Li Juan, Yang Zhen, Xu Mingjing, Luo Changlu, Zhang Kui
Department of Traditional Chinese Medicine, Guizhou Provincial People's Hospital, Zhongshan East Road 83, Guiyang 550001, Guizhou, China.
Department of Rehabilitation Medicine, Tianjin Hospital Tianjin University, Jiefang South Road 406, Tianjin 300211, Tianjin, China.
Open Life Sci. 2022 Sep 14;17(1):1208-1216. doi: 10.1515/biol-2022-0471. eCollection 2022.
Time-related cognitive function refers to the capacity of the brain to store, extract, and process specific information. Previous studies demonstrated that the cerebellar cortex participates in advanced cognitive functions, but the role of the cerebellar cortex in cognitive functions is unclear. We established a behavioral model using classical eyeblink conditioning to study the role of the cerebellar cortex in associative learning and memory and the underlying mechanisms. We performed an investigation to determine whether eyeblink conditioning could be established by placing the stimulating electrode in the middle cerebellar peduncle. Behavior training was performed using a microcurrent pulse as a conditioned stimulus to stimulate the middle cerebellar peduncle and corneal blow as an unconditioned stimulus. After 10 consecutive days of training, a conditioned response was successfully achieved in the Delay, Trace-200-ms, and Trace-300-ms groups of guinea pigs, with acquisition rates of >60%, but the Trace-400-ms and control groups did not achieve a conditioned stimulus-related blink conditioned response. It could be a good model for studying the function of the cerebellum during the establishment of eyeblink conditioning.
与时间相关的认知功能是指大脑存储、提取和处理特定信息的能力。先前的研究表明，小脑皮质参与高级认知功能，但小脑皮质在认知功能中的作用尚不清楚。我们使用经典眨眼条件反射建立了一个行为模型，以研究小脑皮质在联想学习和记忆中的作用及其潜在机制。我们进行了一项研究，以确定通过将刺激电极置于小脑中脚是否可以建立眨眼条件反射。行为训练使用微电流脉冲作为条件刺激来刺激小脑中脚，并以角膜吹气作为非条件刺激。经过连续10天的训练，豚鼠的延迟组、痕迹200毫秒组和痕迹300毫秒组成功实现了条件反应，习得率>60%，但痕迹400毫秒组和对照组未实现与条件刺激相关的眨眼条件反应。它可能是研究眨眼条件反射建立过程中小脑功能的一个良好模型。
