Najaflu Meysam, Shahgolzari Mehdi, Bani Farhad, Khosroushahi Ahmad Yari
Student Research Committee, Tabriz University of Medical Sciences, Tabriz 5165665931, Iran.
Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz 5165665931, Iran.
ACS Omega. 2022 Sep 13;7(38):34573-34582. doi: 10.1021/acsomega.2c04484. eCollection 2022 Sep 27.
Heteroatom-doped carbon dots (CDs) with optical absorbance in the near-infrared (NIR) region can provide an opportunity for selective cancer photothermal therapy (PTT). Here, an eco-friendly, simple, cost-efficient, and one-step hydrothermal method was developed to synthesize copper-doped CDs (Cu-doped CDs). The extract as the carbon source was combined with CuSO as the dopant. Microscopic and spectroscopic analyses showed that spherical and monodisperse Cu-doped CDs (Cu-dCDs) with sizes below 10 nm have bright fluorescence with photoluminescence quantum yields of 11.1%. Cu-dCDs exhibited an excellent single absorbance peak at 800 nm and strong emission at 460 nm when excited at 370 nm. In vitro low cytotoxicity and the Cu-dCD-mediated cell PTT with the photothermal conversion efficiency (39.3%) show that cell internalization of Cu-doped CDs under an 800 nm NIR laser can induce cell thermal death.
在近红外（NIR）区域具有光吸收能力的杂原子掺杂碳点（CDs）可为选择性癌症光热疗法（PTT）提供契机。在此，开发了一种环保、简单、经济高效的一步水热法来合成铜掺杂碳点（Cu掺杂CDs）。以提取物作为碳源，并与硫酸铜作为掺杂剂相结合。微观和光谱分析表明，尺寸小于10 nm的球形且单分散的Cu掺杂碳点（Cu-dCDs）具有明亮的荧光，光致发光量子产率为11.1%。当在370 nm激发时，Cu-dCDs在800 nm处呈现出优异的单吸收峰，在460 nm处有强发射。体外低细胞毒性以及Cu-dCD介导的细胞光热疗法（光热转换效率为39.3%）表明，在800 nm近红外激光照射下，Cu掺杂碳点的细胞内化可诱导细胞热死亡。
