Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and Sexually Transmitted Infections (STIs), Chinese Academy of Medical Sciences and Peking Union Medical College, Institute of Dermatology, Nanjing, China.
Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
Front Cell Infect Microbiol. 2022 Aug 12;12:900895. doi: 10.3389/fcimb.2022.900895. eCollection 2022.
Fungal infections are global public health problems and can lead to substantial human morbidity and mortality. Current antifungal therapy is not satisfactory, especially for invasive, life-threatening fungal infections. Modulating the antifungal capacity of the host immune system is a feasible way to combat fungal infections. Neutrophils are key components of the innate immune system that resist fungal pathogens by releasing reticular extracellular structures called neutrophil extracellular traps (NETs). When compared with phagocytosis and oxidative burst, NETs show better capability in terms of trapping large pathogens, such as fungi. This review will summarize interactions between fungal pathogens and NETs. Molecular mechanisms of fungi-induced NETs formation and defensive strategies used by fungi are also discussed.
真菌感染是全球性的公共卫生问题，可导致严重的人类发病率和死亡率。目前的抗真菌治疗并不令人满意，尤其是对于侵袭性、危及生命的真菌感染。调节宿主免疫系统的抗真菌能力是对抗真菌感染的一种可行方法。中性粒细胞是先天免疫系统的关键组成部分，通过释放称为中性粒细胞胞外陷阱（NETs）的网状细胞外结构来抵抗真菌病原体。与吞噬作用和氧化爆发相比，NETs 在捕获大型病原体（如真菌）方面表现出更好的能力。本综述将总结真菌病原体与 NETs 之间的相互作用。还讨论了真菌诱导 NETs 形成的分子机制以及真菌使用的防御策略。
