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特发性嗜酸性粒细胞增多综合征

The idiopathic hypereosinophilic syndrome.

作者信息

Alfaham M A, Ferguson S D, Sihra B, Davies J

出版信息

Arch Dis Child. 1987 Jun;62(6):601-13. doi: 10.1136/adc.62.6.601.

Abstract

A 14 year old girl with idiopathic hypereosinophilic syndrome is described. In addition to weight loss, anaemia, amenorrhoea, general lethargy, anorexia, mouth ulcers, blisters of hands and feet, and petechial skin rash, she had features of involvement of the cardiovascular system as the major complication. She responded well to treatment. After a comprehensive search of the published reports 18 cases of this syndrome were identified in children under 16 years. Fifteen of these children had involvement of the cardiovascular system as the major source of their morbidity and mortality. Summary of the clinical details and laboratory, biopsy, and necropsy findings of the involvement of the various organ systems of the 18 children is presented.

摘要

本文描述了一名患有特发性嗜酸性粒细胞增多综合征的14岁女孩。除体重减轻、贫血、闭经、全身乏力、厌食、口腔溃疡、手足水疱和瘀点性皮疹外,她还出现了心血管系统受累的特征,这是主要并发症。她对治疗反应良好。在全面检索已发表的报告后,共确定了18例16岁以下儿童患有该综合征。其中15名儿童的心血管系统受累是其发病和死亡的主要原因。本文呈现了这18名儿童各器官系统受累的临床细节、实验室检查、活检及尸检结果的总结。

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本文引用的文献

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Pituitary adrenocorticotropic hormone (ACTH) therapy in eosinophilic leukemia; preliminary report.
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