Tupper G T, Evermann J F, Russell R G, Thouless M E
Arch Virol. 1987;96(1-2):29-38. doi: 10.1007/BF01310988.
Antigenically related feline coronaviruses cause two distinct disease manifestations in infected cats. The diseases are feline infectious peritonitis (FIP), in which the virus is widely disseminated, and feline enteric coronavirus (FECV), a mild disease in which the virus is usually limited to the villi. These two viruses were found to differ in their growth in cell culture. FIPV grows to higher titer, forms larger plaques and switches off host cell protein synthesis more effectively than FECV. Cross neutralization studies showed antigenic differences between the strains. There also appeared to be a difference in the nucleoprotein molecular weight of the viruses causing these two different disease syndromes.
抗原相关的猫冠状病毒在受感染的猫中会引发两种截然不同的疾病表现。这两种疾病分别是猫传染性腹膜炎(FIP),病毒在其中广泛传播;以及猫肠道冠状病毒(FECV),一种轻度疾病,病毒通常局限于绒毛。人们发现这两种病毒在细胞培养中的生长情况有所不同。FIPV比FECV生长至更高滴度,形成更大的噬菌斑,并且更有效地关闭宿主细胞蛋白质合成。交叉中和研究显示了各毒株之间的抗原差异。导致这两种不同疾病综合征的病毒在核蛋白分子量上似乎也存在差异。