Hokmabadi Fahimeh, Zadmard Reza, Jalali Mohammad Reza, Abaee M Saeed
Department of Organic Chemistry, Chemistry and Chemical Engineering Research Center of Iran P. O. Box 14335-186 Tehran Iran
RSC Adv. 2022 Sep 5;12(39):25123-25132. doi: 10.1039/d2ra04530c.
A novel calix[4]arene-bonded silica gel (C4BS) is prepared by covalent attachment of a calix[4]arene derivative to silica gel through a thiol-ene process. The structure and properties of C4BS were studied by Fourier Transform Infra-Red (FTIR) spectroscopy, thermal gravimetric analysis (TGA), elemental analysis (CHN), scanning electron microscopy (SEM), and surface area analysis (BET). In addition, the binding affinity of some antidiabetic drugs towards C4BS was investigated, by quantitative measurement of the drugs in aqueous solution using UV-visible spectroscopy. Results showed that C4BS has higher affinities than plain silica gel for binding to empagliflozin, dapagliflozin and linagliptin at neutral pH, while metformin hydrochloride was not adsorbed efficiently using either C4BS or plain silica gel. Thus, C4BS can be introduced as a promising binder for selective adsorption of the quoted antidiabetic drugs in pharmaceutical effluents, while being reusable by aqueous/acetonitrile (1 : 1) extraction.
通过硫醇-烯反应将杯[4]芳烃衍生物共价连接到硅胶上，制备了一种新型杯[4]芳烃键合硅胶（C4BS）。采用傅里叶变换红外光谱（FTIR）、热重分析（TGA）、元素分析（CHN）、扫描电子显微镜（SEM）和比表面积分析（BET）对C4BS的结构和性能进行了研究。此外，通过紫外可见光谱定量测定水溶液中的药物，研究了一些抗糖尿病药物对C4BS的结合亲和力。结果表明，在中性pH条件下，C4BS对恩格列净、达格列净和利那格列汀的结合亲和力高于普通硅胶，而盐酸二甲双胍无论是使用C4BS还是普通硅胶都不能被有效吸附。因此，C4BS可作为一种有前景的吸附剂，用于选择性吸附制药废水中上述抗糖尿病药物，同时可通过水/乙腈（1∶1）萃取实现重复使用。
