Cui Zhiwei, Mo Jiantao, Song Ping, Wang Lijun, Wang Rongli, Cheng Feiyan, Wang Lihui, Zou Fan, Guan Xin, Zheng Nini, Yang Xinyuan, Wang Wei
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Front Genet. 2022 Sep 20;13:1000339. doi: 10.3389/fgene.2022.1000339. eCollection 2022.
Anillin (ANLN) is a unique scaffolding, actin-binding protein, which is essential for the integrity and ingression of the cleavage furrow. It is mainly involved in the cytokinesis process, while its role in various tumors has not been fully addressed and remains largely elusive. To provide a thorough perspective of ANLN's roles among diverse malignancies, we conducted a comprehensive, pan-cancer analysis about ANLN, including but not limited to gene expression levels, prognostic value, biological functions, interacting proteins, immune-related analysis, and predictive value. As a result, when compared to normal tissues, ANLN expression is elevated in most cancers, and its expression also differs in different immune subtypes and molecular subtypes in diverse cancers. In addition, in 17 types of cancer, ANLN expression is increased in early tumor stages, and higher ANLN expression predicts worse survival outcomes in more than ten cancers. Furthermore, ANLN shows close correlations with the infiltration levels of most immune cells, and enrichment analysis using ANLN co-expressed genes reveals that ANLN plays essential roles in cell cycle, mitosis, cellular senescence, and p53 signaling pathways. In the final, ANLN exhibits high accuracy in predicting many cancers, and subsequent multivariate analysis suggests ANLN could be an independent prognostic factor in specific cancer types. Taken together, ANLN is proved to be a novel and promising biomarker for its excellent predictive utility, promising prognostic value, and potential immunological roles in pan-cancer. Targeting ANLN might be an attractive approach to tumor treatment.
锚蛋白（ANLN）是一种独特的支架肌动蛋白结合蛋白，对分裂沟的完整性和内陷至关重要。它主要参与胞质分裂过程，但其在各种肿瘤中的作用尚未得到充分研究，仍 largely 难以捉摸。为了全面了解 ANLN 在多种恶性肿瘤中的作用，我们对 ANLN 进行了全面的泛癌分析，包括但不限于基因表达水平、预后价值、生物学功能、相互作用蛋白、免疫相关分析和预测价值。结果表明，与正常组织相比，ANLN 在大多数癌症中表达升高，并且在不同癌症的不同免疫亚型和分子亚型中其表达也有所不同。此外，在 17 种癌症中，ANLN 在肿瘤早期阶段表达增加，并且在十多种癌症中，较高的 ANLN 表达预示着较差的生存结果。此外，ANLN 与大多数免疫细胞的浸润水平密切相关，使用 ANLN 共表达基因进行的富集分析表明，ANLN 在细胞周期、有丝分裂、细胞衰老和 p53 信号通路中起重要作用。最后，ANLN 在预测多种癌症方面表现出高准确性，随后的多变量分析表明 ANLN 可能是特定癌症类型中的独立预后因素。综上所述，ANLN 因其出色的预测效用、有前景的预后价值以及在泛癌中的潜在免疫作用而被证明是一种新颖且有前景的生物标志物。靶向 ANLN 可能是一种有吸引力的肿瘤治疗方法。
