Shenzhen Key Laboratory of Smart Healthcare Engineering Guangdong Provincial Key Laboratory of Advanced Biomaterials Department of Biomedical Engineering, Southern University of Science and Technology (SUSTech), Shenzhen, 518055, P. R. China.
ChemistryOpen. 2022 Oct;11(10):e202200137. doi: 10.1002/open.202200137.
The exploration of advanced probes for cancer diagnosis and treatment is of high importance in fundamental research and clinical practice. In comparison with the traditional "always-on" probes, the emerging activatable probes enjoy advantages in promoted accuracy for tumor theranostics by specifically releasing or activating fluorophores at the targeting sites. The main designing principle for these probes is to incorporate responsive groups that can specifically react with the biomarkers (e. g., enzymes) involved in tumorigenesis and progression, realizing the controlled activation in tumors. In this review, we summarize the latest advances in the molecular design and biomedical application of enzyme-responsive organic fluorescent probes. Particularly, the fluorophores can be endowed with ability of generating reactive oxygen species (ROS) to afford the photosensitizers, highlighting the potential of these probes in simultaneous tumor imaging and therapy with rational design. We hope that this review could inspire more research interests in the development of tumor-targeting theranostic probes for advanced biological studies.
癌症诊断和治疗的先进探针的探索在基础研究和临床实践中具有重要意义。与传统的“常开”探针相比，新兴的可激活探针通过在靶向部位特异性释放或激活荧光团，在提高肿瘤治疗的准确性方面具有优势。这些探针的主要设计原则是结合响应基团，这些响应基团可以特异性地与肿瘤发生和进展相关的生物标志物（例如酶）反应，从而在肿瘤中实现控制激活。在本文中，我们总结了酶响应有机荧光探针在分子设计和生物医学应用方面的最新进展。特别地，荧光团可以赋予产生活性氧物种 (ROS) 的能力以提供光敏剂，突出了这些探针在合理设计下进行肿瘤成像和治疗的同时进行的潜力。我们希望这篇综述能够激发更多研究兴趣，以开发用于高级生物学研究的肿瘤靶向治疗探针。
