Programa de Pós-Graduação em Medicina Tropical e Saúde Pública, Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, GO, Brasil.
Laboratório de Nano & Biotecnologia, Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, GO, Brasil.
Curr Med Chem. 2023;30(29):3315-3334. doi: 10.2174/0929867329666221006113536.
Drug delivery systems based on nanotechnology exhibit a number of advantages over traditional pharmacological formulations. Polymeric nanoparticles are commonly used as delivery systems and consist of synthetic or natural polymers that protect drugs from degradation in physiological environments. In this context, indolamine melatonin has been associated with several biological functions, including antioxidant, antitumor, immunoregulatory, neuroprotective, and cardioprotective effects. However, its availability, half-life, and absorption depend upon the route of administration, and this can limit its therapeutic potential. An alternative is the use of polymeric nanoparticle formulations associated with melatonin to increase its bioavailability and therapeutic dose at sites of interest. Thus, the objective of this review is to provide a general and concise approach to the therapeutic association between melatonin and polymeric nanoparticles applied to different biological disorders and to also highlight its advantages and potential applications compared to those of the typical drug formulations that are available.
基于纳米技术的药物传递系统相较于传统的药理学制剂具有许多优势。聚合物纳米粒子通常被用作药物传递系统，由保护药物免受生理环境中降解的合成或天然聚合物组成。在这种情况下，吲哚胺褪黑素与许多生物学功能相关，包括抗氧化、抗肿瘤、免疫调节、神经保护和心脏保护作用。然而，其可用性、半衰期和吸收取决于给药途径，这可能会限制其治疗潜力。一种替代方法是使用与褪黑素相关的聚合物纳米粒子制剂来增加其在感兴趣部位的生物利用度和治疗剂量。因此，本综述的目的是提供一种通用且简洁的方法来研究褪黑素与聚合物纳米粒子之间的治疗关联，该方法适用于不同的生物学紊乱，并强调其与现有典型药物制剂相比的优势和潜在应用。
