Moghimi S Moein
Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, Brighton, UK.
Anticancer Agents Med Chem. 2006 Nov;6(6):553-561. doi: 10.2174/187152006778699130.
Promising results have come from attempts to direct drugs, nucleic acids and diagnostic agents to tumours by using polymeric nanoparticles. Such carriers are versatile; their encapsulation capacity, drug release profile, and biological performance vary with their chemical makeup, morphology, and size. Polymeric nanoparticles may therefore be engineered for therapeutic and diagnostic purposes in accordance with the type, developmental stage and location of the cancer as well as the required route of administration. This article examines recent developments in design and engineering of polymeric nanoparticles and related platforms to include supramolecular systems such as nanocapsules and nanoparticle-based hydrogels, and assesses their potential diagnostic and therapeutic applications in experimental and clinical oncology.
通过使用聚合物纳米颗粒将药物、核酸和诊断剂导向肿瘤的尝试已取得了有前景的结果。这类载体具有多种功能；它们的包封能力、药物释放特性和生物学性能会因其化学组成、形态和大小而有所不同。因此，聚合物纳米颗粒可以根据癌症的类型、发展阶段和位置以及所需的给药途径进行设计，用于治疗和诊断目的。本文探讨了聚合物纳米颗粒及相关平台（包括纳米胶囊和基于纳米颗粒的水凝胶等超分子系统）在设计和工程方面的最新进展，并评估了它们在实验和临床肿瘤学中的潜在诊断和治疗应用。
