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Nilotinib: from animal-based studies to clinical investigation in Alzheimer's disease patients.

作者信息

Nobili Annalisa, D'Amelio Marcello, Viscomi Maria Teresa

机构信息

Department of Medicine and Surgery, University Campus Bio-Medico; Department of Experimental Neuroscience, IRCCS Santa Lucia Foundation, Rome, Italy.

Department of Life Science and Public Health Section of Histology and Embryology, Università Cattolica del Sacro Cuore; Fondazione Policlinico Universitario "A. Gemelli", IRCCS, Rome, Italy.

出版信息

Neural Regen Res. 2023 Apr;18(4):803-804. doi: 10.4103/1673-5374.350700.

DOI:10.4103/1673-5374.350700
PMID:36204843
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9700081/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5218/9700081/95d309ea9fa8/NRR-18-803-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5218/9700081/95d309ea9fa8/NRR-18-803-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5218/9700081/95d309ea9fa8/NRR-18-803-g001.jpg

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Alzheimers Res Ther. 2021 Nov 12;13(1):187. doi: 10.1186/s13195-021-00925-1.
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Aging Dis. 2021 Apr 1;12(2):441-465. doi: 10.14336/AD.2020.0910. eCollection 2021 Apr.
3
Nilotinib restores memory function by preventing dopaminergic neuron degeneration in a mouse model of Alzheimer's Disease.
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Front Mol Biosci. 2024 Oct 31;11:1490275. doi: 10.3389/fmolb.2024.1490275. eCollection 2024.
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Nilotinib as a Prospective Treatment for Alzheimer's Disease: Effect on Proteins Involved in Neurodegeneration and Neuronal Homeostasis.尼罗替尼作为阿尔茨海默病的一种潜在治疗方法:对参与神经退行性变和神经元稳态的蛋白质的影响。
Life (Basel). 2024 Sep 28;14(10):1241. doi: 10.3390/life14101241.
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