Deb Sushanta
Department of Molecular Biology and Bioinformatics, Tripura University, Suryamaninagar, 799022, Tripura, India.
All India Institute of Medical Sciences (AIIMS), New Delhi, 110029, India.
World J Microbiol Biotechnol. 2022 Oct 7;38(12):231. doi: 10.1007/s11274-022-03430-1.
Previous studies were mainly focused on genomic evolution and diversity of type species of Bifidobacterium genus due to their health-promoting effect on host. However, those studies were mainly based on species-level taxonomic resolution, adaptation, and characterization of carbohydrate metabolic features of the bifidobacterial species. Here, a comprehensive analysis of the type strain genome unveils the association of pan-genome evolution with the divergence of metabolic function of the Bifidobacterium genus. This study has also demonstrated that horizontal gene transfer, as well as genome expansion and reduction events, leads to the divergence of metabolic functions in Bifidobacterium genus. Furthermore, the genome-based search of probiotic traits among all the available bifidobacterial type strains gives hints on type species, that could confer health benefits to nutrient-deficient individuals. Altogether, the present study provides insight into the developments of genomic evolution, functional divergence, and potential probiotic type species of the Bifidobacterium genus.
由于双歧杆菌属模式种对宿主具有促进健康的作用，以往的研究主要集中在其基因组进化和多样性方面。然而，这些研究主要基于双歧杆菌物种的物种水平分类分辨率、适应性以及碳水化合物代谢特征的表征。在此，对模式菌株基因组的全面分析揭示了双歧杆菌属泛基因组进化与代谢功能差异之间的关联。该研究还表明，水平基因转移以及基因组的扩增和缩减事件导致了双歧杆菌属代谢功能的差异。此外，在所有可用的双歧杆菌模式菌株中基于基因组搜索益生菌特性，为可能对营养缺乏个体带来健康益处的模式种提供了线索。总之，本研究为双歧杆菌属的基因组进化、功能差异以及潜在益生菌模式种的发展提供了见解。
