通过多维胰腺表型分析了解 2 型糖尿病中的胰岛功能障碍：人类胰腺分析计划。
Understanding islet dysfunction in type 2 diabetes through multidimensional pancreatic phenotyping: The Human Pancreas Analysis Program.
机构信息
Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania, Philadelphia, PA 19104, USA; The Human Pancreas Analysis Program (RRID: SCR_016202).
Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; The Human Pancreas Analysis Program (RRID: SCR_016202).
出版信息
Cell Metab. 2022 Dec 6;34(12):1906-1913. doi: 10.1016/j.cmet.2022.09.013. Epub 2022 Oct 6.
Abstract
In this perspective, we provide an overview of a recently established National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) initiative, the Human Pancreas Analysis Program for Type 2 Diabetes (HPAP-T2D). This program is designed to define the molecular pathogenesis of islet dysfunction by studying human pancreatic tissue samples from organ donors with T2D. HPAP-T2D generates detailed datasets of physiological, histological, transcriptomic, epigenomic, and genomic information. Importantly, all data collected, generated, and analyzed by HPAP-T2D are made immediately and freely available through a centralized database, PANC-DB, thus providing a comprehensive data resource for the diabetes research community.
摘要
在这个视角下，我们提供了一个最近成立的美国国立糖尿病、消化和肾脏疾病研究所（NIDDK）计划的概述，即 2 型糖尿病人类胰腺分析计划（HPAP-T2D）。该计划旨在通过研究患有 2 型糖尿病的器官捐献者的胰腺组织样本，来定义胰岛功能障碍的分子发病机制。HPAP-T2D 生成了详细的生理、组织学、转录组学、表观基因组学和基因组学信息数据集。重要的是，HPAP-T2D 收集、生成和分析的所有数据都通过一个集中的数据库 PANC-DB 立即免费提供，从而为糖尿病研究界提供了一个全面的数据资源。
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