Panhuber H, Laing D G
Brain Res. 1987 Jul;431(1):133-40. doi: 10.1016/0165-3806(87)90202-1.
Rats were exposed to a moderate concentration of ethyl acetoacetate, amyl acetate, cyclohexanone or heptanol, for 69 days from postnatal day 1, whilst other rats were exposed to deodorized air, or the normal range of rat colony odors (Controls). The size of approximately 3% of all mitral cells in the olfactory bulb were measured using a computer-assisted method. As in previous studies in which stimulation began at day 14 or later, some regions of the olfactory bulb had cells that were significantly smaller than those of controls, and rats exposed to deodorized air generally had the smallest cells. Unlike in earlier studies, however, some regions of the olfactory bulb had cells that were significantly larger than similar regions of controls. The distribution of these changes appears to be odor-specific and consists of coronal patterns that extend throughout the rostro-caudal extent of the bulb. The different patterns obtained for the 4 odors used in this study provide evidence for a topographic coding of odor quality at the level of the mitral cells.
从出生后第1天起，将大鼠暴露于中等浓度的乙酰乙酸乙酯、乙酸戊酯、环己酮或庚醇中69天，而其他大鼠则暴露于除臭空气中，或暴露于正常范围的大鼠群体气味中（对照组）。使用计算机辅助方法测量嗅球中所有二尖瓣细胞中约3%的大小。正如之前在出生后第14天或更晚开始刺激的研究一样，嗅球的一些区域有明显小于对照组的细胞，暴露于除臭空气中的大鼠通常细胞最小。然而，与早期研究不同的是，嗅球的一些区域有明显大于对照组相似区域的细胞。这些变化的分布似乎是气味特异性的，由贯穿嗅球前后范围的冠状模式组成。本研究中使用的4种气味所获得的不同模式为二尖瓣细胞水平上气味质量的地形编码提供了证据。
