血浆致动脉粥样硬化指数与不同年龄段男性冠心病的相关性：一项回顾性研究。
Correlation between atherogenic index of plasma and coronary artery disease in males of different ages: a retrospective study.
机构信息
Department of Cardiology, Heart Center, Zhujiang Hospital, Southern Medical University, NO. 253, Gongye Avenue, Guangzhou, 510282, China.
Guangdong Provincial Biomedical Engineering Technology Research Center for Cardiovascular Disease, NO. 253, Gongye Avenue, Guangzhou, 510282, China.
出版信息
BMC Cardiovasc Disord. 2022 Oct 9;22(1):440. doi: 10.1186/s12872-022-02877-2.
BACKGROUND
Atherogenic index of plasma (AIP) as a newly discovered blood lipid parameter was shown to be strongly correlated with coronary artery disease (CAD). However, the blood lipid levels changed with age, so we speculated that the correlation between AIP and CAD was also affected by age.
METHODS
A retrospective study was performed on male patients with confirmed or suspected CAD who underwent coronary angiography (CAG) from July 2017 to March 2021. Patients were divided into younger, middle early, middle late, and elderly groups. Patients in each age group were further divided into the non-coronary artery disease (n-CAD) and CAD subgroups according to the CAG diagnostic results. The relationship between blood lipid parameters and CAD was assessed in each age group.
RESULTS
Age-dependent changes of blood lipid levels were mainly found in CAD patients but not in n-CAD patients. With increased age, the levels of triglyceride, total cholesterol, low-density lipoprotein cholesterol (LDL-C) and AIP were gradually decreased, whereas high-density lipoprotein cholesterol concentration was increased in CAD patients. Multivariate logistic regression analyses showed that AIP was an independent risk factor for CAD in middle early (OR 2.601; CI 1.160-5.832, P = 0.02) and middle late age group (OR 2.707, CI 1.201-6.100, P = 0.016), but not in the younger and elderly groups. LDL-C was an independent risk factor for CAD in all age groups. The areas under curve of AIP for detecting CAD in the middle early and middle late age groups were not higher than that of other blood lipid parameters.
CONCLUSION
Although this was a single-center study for males only, the correlation between AIP level and CAD risk was age-dependent. AIP was an independent risk factor for CAD in the middle-aged groups. However, the predictive value of AIP for detecting CAD was not better than that of the traditional blood lipid parameters such as LDL-C.
背景
血浆致动脉粥样硬化指数（AIP）作为一种新发现的血脂参数，与冠状动脉疾病（CAD）密切相关。然而，血脂水平随年龄而变化，因此我们推测 AIP 与 CAD 的相关性也受年龄影响。
方法
对 2017 年 7 月至 2021 年 3 月间因疑似或确诊 CAD 而行冠状动脉造影（CAG）的男性患者进行回顾性研究。将患者分为年轻、中早期、中晚期和老年组。根据 CAG 诊断结果，将每组患者进一步分为非冠状动脉疾病（n-CAD）和 CAD 亚组。评估各年龄组中血脂参数与 CAD 的关系。
结果
主要在 CAD 患者中发现血脂水平随年龄变化的趋势，但在 n-CAD 患者中未见这种变化。随着年龄的增长，CAD 患者的甘油三酯、总胆固醇、低密度脂蛋白胆固醇（LDL-C）和 AIP 水平逐渐降低，而高密度脂蛋白胆固醇浓度逐渐升高。多变量逻辑回归分析显示，AIP 是中早期（OR 2.601；CI 1.160-5.832，P=0.02）和中晚期（OR 2.707，CI 1.201-6.100，P=0.016）CAD 的独立危险因素，但在年轻和老年组中并非如此。LDL-C 是所有年龄组 CAD 的独立危险因素。AIP 检测 CAD 的曲线下面积在中早期和中晚期年龄组中均未高于其他血脂参数。
结论
尽管这是一项仅针对男性的单中心研究，但 AIP 水平与 CAD 风险的相关性是年龄依赖性的。AIP 是中年组 CAD 的独立危险因素。然而，AIP 预测 CAD 的价值并不优于 LDL-C 等传统血脂参数。
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