预测立陶宛中老年人群全因和心血管疾病死亡率的内脏脂肪指数和血浆致动脉粥样硬化指数的重要性。
Predictive importance of the visceral adiposity index and atherogenic index of plasma of all-cause and cardiovascular disease mortality in middle-aged and elderly Lithuanian population.
机构信息
Institute of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Department of Environmental and Occupational Medicine, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
出版信息
Front Public Health. 2023 Mar 13;11:1150563. doi: 10.3389/fpubh.2023.1150563. eCollection 2023.
BACKGROUND
Two indices: visceral adiposity index (VAI) and atherogenic index of plasma (AIP) during several recent years were implemented into epidemiological studies for predicting of cardiovascular diseases (CVD) and mortality risk. Our study aimed to evaluate the association of VAI and AIP with the risk of all-cause and CVD mortality among the Lithuanian urban population aged 45-72 years.
METHODS
In the baseline survey (2006-2008), 7,115 men and women 45-72 years of age were examined within the framework of the international study Health, Alcohol and Psychosocial Factors in Eastern Europe (HAPIEE). Six thousand six hundred and seventy-one participants (3,663 women and 3,008 men) were available for statistical analysis (after excluding 429 respondents with the missed information on study variables) and for them, VAI and AIP were calculated. The questionnaire evaluated lifestyle behaviors, including smoking and physical activity. All participants in the baseline survey were followed up for all-cause and CVD mortality events until December 31st, 2020. Multivariable Cox regression models were applied for statistical data analysis.
RESULTS
After accounting for several potential confounders, higher levels of VAI (compared 5th quintile to 1st quintile) were associated with significantly higher CVD mortality in men [Hazards ratio (HR) = 1.38] and all-cause mortality in women (HR = 1.54) after 10-year follow-up. CVD mortality significantly increased in men with 0 the highest AIP quintile compared with that for the lowest quintile (HR = 1.40). In women, all-cause mortality was significantly higher for the 4th quintile of AIP as compared with the 1st quintile (HR = 1.36).
CONCLUSIONS
High-risk VAI levels were statistically significantly associated with all-cause mortality risk in men and women groups. The higher AIP level (5th quintile vs. 1st quintile-in men and 4th quintile vs. 1st quintile-in women) was significantly associated with increased mortality from CVD in the men group and increased all-cause mortality in the women group.
背景
近年来，内脏脂肪指数（VAI）和血浆致动脉粥样硬化指数（AIP）这两个指数已被纳入流行病学研究，用于预测心血管疾病（CVD）和死亡风险。我们的研究旨在评估 VAI 和 AIP 与立陶宛城市 45-72 岁人群全因和 CVD 死亡率风险的相关性。
方法
在基线调查（2006-2008 年）中，在国际研究“东欧健康、酒精和心理社会因素（HAPIEE）”的框架内，对 7115 名 45-72 岁的男性和女性进行了检查。6671 名参与者（3663 名女性和 3008 名男性）可用于统计分析（排除了 429 名研究变量信息缺失的受访者），并为他们计算了 VAI 和 AIP。调查问卷评估了生活方式行为，包括吸烟和体育活动。基线调查中的所有参与者均随访至 2020 年 12 月 31 日，以了解全因和 CVD 死亡事件。多变量 Cox 回归模型用于统计数据分析。
结果
在考虑了几个潜在的混杂因素后，与第 5 个五分位数相比，VAI 水平较高（第 1 个五分位数）与男性 CVD 死亡率（HR = 1.38）和女性全因死亡率（HR = 1.54）显著相关，随访 10 年后。与最低五分位数相比，男性中最高 AIP 五分位数的 CVD 死亡率显著增加（HR = 1.40）。在女性中，与第 1 个五分位数相比，第 4 个五分位数的 AIP 与全因死亡率显著升高（HR = 1.36）。
结论
高风险的 VAI 水平与男性和女性全因死亡率风险具有统计学显著相关性。在男性中，较高的 AIP 水平（第 5 个五分位数比第 1 个五分位数-和女性中第 4 个五分位数比第 1 个五分位数-）与 CVD 死亡率增加相关，而女性的全因死亡率增加。
Zotero 插件