Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, People's Republic of China.
Angiology. 2021 Nov;72(10):934-941. doi: 10.1177/00033197211012129. Epub 2021 May 5.
We evaluated the predictive power of the atherogenic index of plasma (AIP) for coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM). A total of 3278 patients who underwent coronary angiography were consecutively enrolled, including 2052 patients with CAD and 1226 patients with T2DM but without CAD. Patients in the CAD group had higher levels of triglyceride (TG), total cholesterol, low-density lipoprotein cholesterol, AIP and a lower level of high-density lipoprotein cholesterol (HDL-C). In correlation analyses, AIP correlated positively with body mass index, log (homeostasis model assessment of insulin resistance), TG, remnant lipoprotein cholesterol, non-HDL-C, but negatively with age and HDL-C. Multivariate logistic regression analyses demonstrated that AIP was an independent risk factor for CAD in diabetic patients and was validated by multiple models. Furthermore, the ORs for CAD risk were raised with increasing AIP quartiles; ORs of AIP quartiles Q2-Q4 compared with Q1 were 1.56, 1.70, and 2.22, respectively (s < .001), which suggested AIP was the lipid parameter that most strongly associated with incident CAD. In conclusion, AIP is a powerful and reliable biomarker for predicting CAD risk beyond individual lipid profiles in patients with T2DM.
我们评估了血浆致动脉粥样硬化指数（AIP）对 2 型糖尿病（T2DM）患者冠心病（CAD）的预测能力。共连续纳入 3278 例接受冠状动脉造影的患者，包括 2052 例 CAD 患者和 1226 例无 CAD 的 T2DM 患者。CAD 组患者的甘油三酯（TG）、总胆固醇、低密度脂蛋白胆固醇、AIP 水平较高，而高密度脂蛋白胆固醇（HDL-C）水平较低。在相关分析中，AIP 与体重指数、log（胰岛素抵抗稳态模型评估）、TG、残粒脂蛋白胆固醇、非高密度脂蛋白胆固醇呈正相关，与年龄和 HDL-C 呈负相关。多变量逻辑回归分析表明，AIP 是糖尿病患者 CAD 的独立危险因素，并通过多个模型得到验证。此外，随着 AIP 四分位数的增加，CAD 风险的 OR 也升高；与 Q1 相比，AIP 四分位数 Q2-Q4 的 OR 分别为 1.56、1.70 和 2.22（P<.001），这表明 AIP 是与新发 CAD 相关性最强的脂质参数。总之，AIP 是预测 T2DM 患者 CAD 风险的有力且可靠的生物标志物，超越了个体血脂谱。
