Yin Beibei, Wang Xuan, Yuan Fang, Li Yan, Lu Ping
Department of Oncology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine, Shandong Lung Cancer Institute, Jinan, China.
Department of Digestive Endoscopy, The Affiliated Hospital of Shandong University of TCM, Jinan, China.
Front Microbiol. 2022 Sep 23;13:899111. doi: 10.3389/fmicb.2022.899111. eCollection 2022.
Chemotherapy is one of the most effective methods of systemic cancer treatment. Chemotherapy drugs are delivered through the blood circulation system, and they can act at all stages of the cell cycle, and can target DNA, topoisomerase, or tubulin to prevent the growth and proliferation of cancer cells. However, due to the lack of specific targets for chemotherapeutic agents, there are still unavoidable complications of cytotoxic effects. The effect of the microbiome on human health is clear. There is growing evidence of the potential relationship between the microbiome and the efficacy of cancer therapy. Gut microbiota can regulate the metabolism of drugs in several ways. The presence of bacteria in the tumor environment can also affect the response to cancer therapy by altering the chemical structure of chemotherapeutic agents and affecting their activity and local concentration. However, the underlying mechanisms by which the gut and tumor microbiota affect cancer therapeutic response are unclear. This review provides an overview of the effects of gut and tumor microbiota on the efficacy and adverse effects of chemotherapy in cancer patients, thus facilitating personalized treatment strategies for cancer patients.
化疗是全身性癌症治疗最有效的方法之一。化疗药物通过血液循环系统输送，它们可以作用于细胞周期的各个阶段，并且可以靶向DNA、拓扑异构酶或微管蛋白以防止癌细胞的生长和增殖。然而，由于化疗药物缺乏特异性靶点，细胞毒性作用的并发症仍然不可避免。微生物群对人类健康的影响是明确的。越来越多的证据表明微生物群与癌症治疗疗效之间存在潜在关系。肠道微生物群可以通过多种方式调节药物代谢。肿瘤环境中细菌的存在还可以通过改变化疗药物的化学结构并影响其活性和局部浓度来影响对癌症治疗的反应。然而，肠道和肿瘤微生物群影响癌症治疗反应的潜在机制尚不清楚。本综述概述了肠道和肿瘤微生物群对癌症患者化疗疗效和不良反应的影响，从而促进癌症患者的个性化治疗策略。
