School of Pharmaceutical Sciencese, South-Central Minzu University, Wuhan 430074, People's Republic of China.
School of Pharmaceutical Sciencese, South-Central Minzu University, Wuhan 430074, People's Republic of China.
Fitoterapia. 2022 Nov;163:105326. doi: 10.1016/j.fitote.2022.105326. Epub 2022 Oct 8.
Chemical investigation on the fruiting bodies of the mushroom Geoglossum fallax led to the isolation of two carboxamides, geoglamides A and B (1 and 2), one meroterpenoid, geoglol A (3), together with seven known metabolites (4-10). Their structures were identified by spectroscopic analyses as well as ECD calculations. Compounds 1 and 2 are rare long chain fatty amides containing a 4-oxo-1,4-dihydropyridine moiety, while compound 3 is a rare C-C type meroterpenoid. Compound 1 displayed cytotoxic activity against human MCF-7 cells with an IC value of 25.9 ± 0.51 μM. compounds 2 and 8 showed weak pancreatic lipase inhibition activity. To our best knowledge, this is the first report of the chemical constituents in the genera Geoglossum and their bioactive activity.
对蘑菇地卷 Geoglossum fallax 的子实体进行化学研究，分离得到两种羧酰胺，即地卷酰胺 A 和 B（1 和 2），一种混合倍半萜烯，即地卷醇 A（3），以及七种已知代谢物（4-10）。通过光谱分析以及 ECD 计算确定了它们的结构。化合物 1 和 2 是罕见的含有 4-氧代-1,4-二氢吡啶部分的长链脂肪酸酰胺，而化合物 3 是一种罕见的 C-C 型混合倍半萜烯。化合物 1 对人 MCF-7 细胞表现出细胞毒性，IC 值为 25.9±0.51μM。化合物 2 和 8 显示出微弱的胰腺脂肪酶抑制活性。据我们所知，这是首次报道地卷属和它们的生物活性物质的化学成分。
