Engineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, Jilin Agricultural University, Changchun, China.
College of Life Science, Jilin Agricultural University, Changchun, China.
Nat Prod Res. 2020 May;34(10):1417-1422. doi: 10.1080/14786419.2018.1509324. Epub 2018 Nov 20.
Phytochemical investigation of the fruiting body of led to the isolation of a new furanone, 2(5)-furanone-4-propionic acid named volvafuranone A (), together with twelve known compounds (). Compounds , were isolated from this mushroom for the first time. The isolated compounds were assessed for their cytotoxicity against four human tumour lines (SGC-7901, PC-3M, MCF-7, HepG-2), and the results showed that compound , , , have significant cytotoxicity with IC values of 5.90 μM (HepG-2), 20.72 μM (HepG-2), 27.98 μM (PC-3M) and 23.15 μM (PC-3M), respectively.
对担子菌的子实体进行植物化学研究，分离得到一种新的呋喃酮，2(5)-呋喃酮-4-丙酸，命名为 volvafuranone A ()，同时还分离得到了 12 种已知化合物 ()。化合物 、 是首次从这种蘑菇中分离得到的。对分离得到的化合物进行了对 4 个人类肿瘤细胞系（SGC-7901、PC-3M、MCF-7、HepG-2）的细胞毒性评估，结果表明，化合物 、 、 、 具有显著的细胞毒性，其 IC 值分别为 5.90 μM（HepG-2）、20.72 μM（HepG-2）、27.98 μM（PC-3M）和 23.15 μM（PC-3M）。
