School of Biomedical Engineering, Sun Yat-sen University, Shenzhen 518107, China.
School of Biomedical Engineering, Sun Yat-sen University, Shenzhen 518107, China.
J Control Release. 2022 Nov;351:752-778. doi: 10.1016/j.jconrel.2022.10.007. Epub 2022 Oct 10.
Prussian blue (PB) nanoparticles possess excellent physicochemical properties, including imaging features, robust photothermal conversion ability, catalytic activity, surface modifiability, effective drug loading, good stability, biocompatibility and biodegradability. With the advancement of nanotechnology, diverse PB-based nanoplatforms have been developed for biomedical applications. This review systematically summarized recent studies on PB-based nanoplatforms in the treatment of tumor (photothermal therapy, photodynamic therapy, chemotherapy, immunotherapy, theranostics, etc.), cardiovascular and cerebrovascular diseases (restenosis, atherosclerosis, thrombosis, ischemic stroke, etc.), bacterial infections (photothermal sterilization, biofilms disruption, etc.), and other inflammation-related diseases (liver injury, acute pancreatitis, inflammatory bowel disease, osteoarthritis, etc.). Finally, the existing challenges associated with current studies are discussed, and the future possible research and application directions for PB-based nanoplatforms are proposed, providing paradigms for subsequent development.
普鲁士蓝（PB）纳米颗粒具有优异的物理化学性质，包括成像特性、强大的光热转换能力、催化活性、表面可修饰性、有效的药物负载、良好的稳定性、生物相容性和生物降解性。随着纳米技术的进步，已经开发出了多种基于 PB 的纳米平台，用于生物医学应用。本综述系统地总结了近年来基于 PB 的纳米平台在肿瘤（光热治疗、光动力治疗、化学治疗、免疫治疗、诊断与治疗一体化等）、心脑血管疾病（再狭窄、动脉粥样硬化、血栓形成、缺血性中风等）、细菌感染（光热杀菌、生物膜破坏等）以及其他炎症相关疾病（肝损伤、急性胰腺炎、炎症性肠病、骨关节炎等）的治疗中的研究进展。最后，讨论了当前研究中存在的挑战，并提出了基于 PB 的纳米平台未来可能的研究和应用方向，为后续的发展提供了范例。
