患有大量代谢综合征风险因素的女性的同时训练与个体间反应
Concurrent training and interindividual response in women with a high number of metabolic syndrome risk factors.
作者信息
Delgado-Floody Pedro, Chirosa-Ríos Luis, Caamaño-Navarrete Felipe, Valdés-Badilla Pablo, Herrera-Valenzuela Tomás, Monsalves-Álvarez Matías, Núñez-Espinosa Cristian, Castro-Sepulveda Mauricio, Guzmán-Muñoz Eduardo, Andrade David C, Álvarez Cristian
机构信息
Department of Physical Education, Sport and Recreation, Universidad de La Frontera, Temuco, Chile.
Department Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Granada, Spain.
出版信息
Front Physiol. 2022 Sep 23;13:934038. doi: 10.3389/fphys.2022.934038. eCollection 2022.
The non-responders (NRs) after exercise training have been poorly studied in populations with morbid obesity. The purpose of this study was to determine the NR prevalence after 20 weeks of concurrent training of morbidly obese women with a high or low number of metabolic syndrome (MetS) risk factors. Twenty-eight women with morbid obesity participated in an exercise training intervention and were allocated into two groups distributed based on a high (≥3, = 11) or low number (<3, = 17) of MetS risk factors. The main outcomes were waist circumference (WC), fasting plasma glucose (FPG), high-density lipids (HDL-c), triglycerides (Tg), and systolic (SBP) and diastolic (DBP) blood pressure, and secondary outcomes were body composition, anthropometric and physical fitness, determined before and after 20 weeks of concurrent training. NRs were defined as previously used technical error cut-off points for the MetS outcomes. Significantly different (all < 0.05) prevalences of NRs between the H-MetS vs. L-MetS groups (respectively) in WC (NRs 18.2 % vs. 41.1 %, < 0.0001), SBP (NRs 72.7 % vs. 47.0 %, = 0.022), DBP (NRs 54.5 % vs. 76.4 %, < 0.0001), FPG (NRs 100% vs. 64.8 %, < 0.0001), and HDL-c (NRs 90.9 % vs. 64.7 %, = 0.012) were observed. In addition, the H-MetS group evidenced significant changes on ΔSBP (-10.2 ± 11.4 mmHg), ΔFPG (-5.8 ± 8.2 mg/dl), ΔHDL-c (+4.0 ± 5.9 mg/dl), and ΔTg (-8.8 ± 33.8 mg/dl), all < 0.05. The L-MetS group only showed significant changes in ΔWC (-3.8 ± 5.0 cm, = 0.009). Comparing H-MetS vs. L-MetS groups, significant differences were observed in ∆FPG (-5.8 ± 8.2 vs. +0.3 ± 3.2 mg/dl, = 0.027), but not in other MetS outcomes. In conclusion, 20 weeks of concurrent training promotes greater beneficial effects in morbidly obese patients with a high number of MetS risk factors. However, the NR prevalence for improving MetS outcomes was significantly superior in these more-diseased groups in SBP, FPG, and HDL-c, independent of their major training-induced effects.
对于病态肥胖人群，运动训练无反应者（NRs）的研究较少。本研究旨在确定患有高或低数量代谢综合征（MetS）危险因素的病态肥胖女性在进行20周联合训练后的NR患病率。28名病态肥胖女性参与了一项运动训练干预，并根据MetS危险因素数量高（≥3，n = 11）或低（<3，n = 17）分为两组。主要结局指标为腰围（WC）、空腹血糖（FPG）、高密度脂蛋白（HDL-c）、甘油三酯（Tg）以及收缩压（SBP）和舒张压（DBP），次要结局指标为身体成分、人体测量指标和体能，在联合训练20周前后进行测定。NRs的定义采用先前用于MetS结局指标的技术误差截止点。在WC（NRs分别为18.2% vs. 41.1%，P < 0.0001）、SBP（NRs分别为72.7% vs. 47.0%，P = 0.022）、DBP（NRs分别为54.5% vs. 76.4%，P < 0.0001）、FPG（NRs分别为100% vs. 64.8%，P < 0.0001）和HDL-c（NRs分别为90.9% vs. 64.7%，P = 0.012）方面，高MetS组与低MetS组之间NRs的患病率存在显著差异（均P < 0.05）。此外，高MetS组在ΔSBP（-10.2 ± 11.4 mmHg）、ΔFPG（-5.8 ± 8.2 mg/dl）、ΔHDL-c（+4.0 ± 5.9 mg/dl）和ΔTg（-8.8 ± 33.8 mg/dl）方面有显著变化，均P < 0.05。低MetS组仅在ΔWC（-3.8 ± 5.0 cm，P = 0.009）方面有显著变化。比较高MetS组与低MetS组，在∆FPG方面存在显著差异（-5.8 ± 8.2 vs. +0.3 ± 3.2 mg/dl，P = 0.027），但在其他MetS结局指标方面无显著差异。总之，20周联合训练对患有大量MetS危险因素的病态肥胖患者具有更大的有益作用。然而，在SBP、FPG和HDL-c方面，改善MetS结局的NR患病率在这些病情更严重的组中显著更高，且独立于其主要的训练诱导效应。
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