von Wright A, Niskanen A, Pyysalo H
Mutat Res. 1978 Oct;54(2):167-73. doi: 10.1016/0165-1161(78)90037-7.
Ethylidene gyromitrin (acetaldehyde-N-methyl-N-formylhydrazone) is the main poisonous hydrazine derivative in the edible mushroom false morel (Gyromitra esculenta Pers. Fr.). The mutagenic properties of this compound, and of its metabolites N-methyl-N-formylhydrazine and N-methylhydrazine, were tested by microsomal activation and host-mediated assay. Histidine auxotroph strains of Salmonella typhimurium were used as indicator organisms. Microsomal preparations had no detectable effect on the biological activity of the compounds tested, but the results of host-mediated assay experiments suggested that a bacteriocidic metabolite is formed from ethylidene gyromitrin.
亚乙基鹿花菌素（乙醛 - N - 甲基 - N - 甲酰腙）是可食用蘑菇鹿花菌（Gyromitra esculenta Pers. Fr.）中的主要有毒肼衍生物。通过微粒体活化和宿主介导试验测试了该化合物及其代谢产物N - 甲基 - N - 甲酰肼和N - 甲基肼的致突变特性。鼠伤寒沙门氏菌的组氨酸营养缺陷型菌株用作指示生物。微粒体制剂对所测试化合物的生物活性没有可检测到的影响，但宿主介导试验实验的结果表明，亚乙基鹿花菌素可形成一种杀菌代谢产物。
