von der Hude W, Braun R
Toxicology. 1983 Feb;26(2):155-60. doi: 10.1016/0300-483x(83)90066-5.
The hepatotoxic and carcinogenic hydrazine N-methyl-N-formyl hydrazine (MFH), which is formed from the mushroom poison gyromitrin by hydrolytic cleavage in vivo and in vitro during food processing is much more mutagenic for the strain TA 100 of Salmonella typhimurium in the presence of a metabolic activation system than in its absence. On the other hand, acetylated MFH (Ac-MFH) was not mutagenic for TA 100 in both test conditions. For the strain TA 98 neither MFH nor Ac-MFH were mutagenic both with and without metabolic activation. Therefore, a metabolic conversion of the free NH2-moiety of MFH into a genotoxic metabolite of MFH is postulated.
肝毒性和致癌性的肼类物质N-甲基-N-甲酰肼（MFH），它是由蘑菇毒素鹿花菌素在体内和体外食物加工过程中通过水解裂解形成的。在有代谢激活系统存在的情况下，MFH对鼠伤寒沙门氏菌TA 100菌株的致突变性比没有该系统时要强得多。另一方面，在两种测试条件下，乙酰化的MFH（Ac-MFH）对TA 100都没有致突变性。对于TA 98菌株，无论有无代谢激活，MFH和Ac-MFH都没有致突变性。因此，推测MFH的游离NH2基团会代谢转化为一种具有遗传毒性的MFH代谢产物。
