Zhang Jin, Xu Xin
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2022 Sep;53(5):929-934. doi: 10.12182/20220960103.
is the first microorganism found to be closely associated with dental caries. It demonstrates acidogenicity, aciduricity, and the ability to bind with collagen and to synthesize extracellular polysaccharides to promote bacterial adhesion. Some lactobacilli inhibit the growth of cariogenic bacteria by producing antibacterial compounds or metabolites, competing with cariogenic bacteria for adhesion sites or co-aggregation, or regulating the expression of genes related to cariogenic virulence. Therefore, researchers have, in recent years, experimented with applying as probiotics in the prevention and control of caries. However, the cariogenic mechanism of is still not fully understood, and the potential effects, presumably beneficial, of specific on oral and intestinal microecology remain unknown. More research needs to be done to combine both the cariogenic and probiotic properties of , and to comprehensively evaluate the effects of on oral and systemic health. We, herein, summarized research progress in the cariogenicity and caries prevention effect of , focusing on a discussion of the role of in cariogenesis, the development of dental caries, and clinical prevention and control of dental caries, in order to provide new ideas and references for the prevention and control of dental caries.
是首个被发现与龋齿密切相关的微生物。它具有产酸性、耐酸性,以及与胶原蛋白结合和合成细胞外多糖以促进细菌黏附的能力。一些乳酸菌通过产生抗菌化合物或代谢产物、与致龋菌竞争黏附位点或共同聚集,或调节与致龋毒力相关的基因表达来抑制致龋菌的生长。因此,近年来研究人员尝试将其作为益生菌应用于龋齿的预防和控制。然而,其致龋机制仍未完全明确,特定的它对口腔和肠道微生态可能有益的潜在影响也尚不清楚。需要开展更多研究来结合它的致龋性和益生菌特性,并全面评估其对口腔和全身健康的影响。在此,我们总结了它在致龋性和防龋效果方面的研究进展,重点讨论它在龋病发生、龋齿发展以及龋齿临床防治中的作用,以便为龋齿的预防和控制提供新思路和参考。