Iturriaga H, Bunout D, Petermann M, Ugarte G, Israel Y
Alcohol Clin Exp Res. 1981 Spring;5(2):221-4. doi: 10.1111/j.1530-0277.1981.tb04892.x.
Hepatic blood flow measured by indocyanine green clearance was studied in rats after an acute intoxicating dose of ethanol (2 g/kg) or after chronic ethanol administration by feeding with alcohol liquid diets. Acute intoxication to normal animals did not modify hepatic blood flow. In chronically alcohol-fed rats, hepatic blood flow was significantly decreased when measured after 15 hr of abstinence. If ethanol was not withdrawn and an acute dose of ethanol was given before the indocyanine green clearance, a decreased hepatic blood flow was not observed. It is suggested that the reduction of hepatic blood flow in recently abstinent chronically alcohol-treated animals is related to the withdrawal syndrome.
通过吲哚菁绿清除率测定肝血流量，对给予急性中毒剂量乙醇（2 g/kg）的大鼠或通过给予酒精液体饲料进行慢性乙醇给药后的大鼠进行了研究。对正常动物的急性中毒并未改变肝血流量。在慢性酒精喂养的大鼠中，戒断15小时后测量时，肝血流量显著降低。如果不停止给予乙醇，在进行吲哚菁绿清除率测定前给予急性剂量的乙醇，则未观察到肝血流量降低。提示近期戒断的慢性酒精处理动物肝血流量的减少与戒断综合征有关。
