Laboratório de Avaliação de Substâncias Bioativas, Departamento de Ciências Naturais, Universidade Regional de Blumenau, CEP 89030-903, Blumenau, Santa Catarina, Brazil.
Empresa de Pesquisa Agropecuária e Extensão Rural de Santa Catarina, EPAGRI, CEP 88318-112, Itajaí, Santa Catarina, Brazil.
Chem Biodivers. 2022 Nov;19(11):e202200242. doi: 10.1002/cbdv.202200242. Epub 2022 Nov 3.
Depression is one of the disorders involving mental health that most affects the population worldwide. Considering the available pharmacological therapies for the treatment of depression are ineffective in most patients, the search for new alternatives is crucial. In line with this, we investigated the phenolic profile, antidepressant-like, and antioxidant effects triggered by the administration of aqueous extracts from Psidium guajava L. (GUA), Psidium cattleianum Sw. (CAT), and Psidium guineense Sabine (GUI) leaves in mice. Our results show that quercetin is the major compound of GUA and GUI, and o-coumaric acid in CAT extracts. The acute and subchronic administrations of the three plant extracts exerted an antidepressant-like effect in mice exposed to the tail suspension test, without changes on locomotor performance evaluated by the open field test. Furthermore, the GUI and CAT decreased oxidative stress markers, mainly lipid peroxidation and nitrites in the hippocampus, prefrontal cortex, liver, and plasma. Notably, GUA and CAT increased non-protein thiols in all tissues. Therefore, the Psidium extracts demonstrated an antidepressant-like effect in mice, and the antioxidant capacity of the extracts seems to underlie the behavioral effect.
抑郁症是影响全球人口最多的精神健康障碍之一。考虑到目前用于治疗抑郁症的药物疗法在大多数患者中无效，因此寻找新的替代方法至关重要。基于此，我们研究了番石榴（GUA）、番樱桃（CAT）和几内亚胡椒（GUI）叶的水提物给药后引发的酚类谱、抗抑郁样和抗氧化作用。我们的结果表明，槲皮素是 GUA 和 GUI 的主要化合物，而 CAT 提取物中的 o-香豆酸。三种植物提取物的急性和亚慢性给药在悬尾试验中表现出抗抑郁样作用，而在旷场试验中评估的运动表现没有变化。此外，GUI 和 CAT 降低了海马体、前额叶皮层、肝脏和血浆中的氧化应激标志物，主要是脂质过氧化和亚硝酸盐。值得注意的是，GUA 和 CAT 增加了所有组织中的非蛋白巯基。因此，Psidium 提取物在小鼠中表现出抗抑郁样作用，而提取物的抗氧化能力似乎是行为作用的基础。
