Laboratorio de Líquido Sinovial, Instituto Nacional de Rehabilitación "Luis Guillermo Ibarra Ibarra", Calzada México-Xochimilco 289, Colonia Arenal de Guadalupe, Tlalpan, 14389 Mexico City, Mexico.
Laboratorio de Gerociencias, Instituto Nacional de Rehabilitación "Luis Guillermo Ibarra Ibarra", Calzada México-Xochimilco 289, Colonia Arenal de Guadalupe, Tlalpan, 14389 Mexico City, Mexico.
Cell Mol Biol (Noisy-le-grand). 2022 Jun 30;68(6):174-184. doi: 10.14715/cmb/2022.68.6.28.
Rheumatoid arthritis (RA) is an autoimmune disease that affects approximately 1% of the worldwide population. In recent decades, oxidative stress (OS) has been shown to be involved in the progression of this disease through DNA, lipid and protein damage, resulting in synovial inflammation. There are many causes of OS; metabolism is involved in the production of reactive oxygen species (ROS) but pollution, diet and microbiota imbalances could lead to the overproduction of these ROS. A decade of research focused on understanding how OS is promoted by known RA risk factors is described herein. The use of antioxidants represents an integrative treatment for patients with rheumatoid arthritis, given the evidence of the damage caused by oxidative stress in this disease. Understanding the different factors that contribute to the development and progression of RA, such as OS, will pave the way not only for better pharmacological treatments but also for recommendations for dietary and health behaviours that will benefit patients with this disease.
类风湿关节炎（RA）是一种自身免疫性疾病，影响全球约 1%的人口。近几十年来，氧化应激（OS）已被证明通过 DNA、脂质和蛋白质损伤参与疾病的进展，导致滑膜炎症。OS 有许多原因；代谢参与活性氧（ROS）的产生，但污染、饮食和微生物群落失衡可能导致这些 ROS 的过度产生。本文描述了过去十年的研究如何集中于了解 OS 如何被已知的 RA 风险因素所促进。鉴于氧化应激在这种疾病中造成的损害，抗氧化剂的使用代表了类风湿关节炎患者的综合治疗方法。了解导致 RA 发展和进展的不同因素，如 OS，不仅将为更好的药物治疗铺平道路，还将为有益于这种疾病患者的饮食和健康行为建议提供依据。
