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巨噬细胞、慢性炎症与胰岛素抵抗。

Macrophages, Chronic Inflammation, and Insulin Resistance.

机构信息

Beijing City Key Laboratory of Drug Delivery Technology and Novel Formulation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.

Shandong DYNE Marine Biopharmaceutical Co., Ltd., Rongcheng 264300, China.

出版信息

Cells. 2022 Sep 26;11(19):3001. doi: 10.3390/cells11193001.

DOI:10.3390/cells11193001
PMID:36230963
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9562180/
Abstract

The prevalence of obesity has reached alarming levels, which is considered a major risk factor for several metabolic diseases, including type 2 diabetes (T2D), non-alcoholic fatty liver, atherosclerosis, and ischemic cardiovascular disease. Obesity-induced chronic, low-grade inflammation may lead to insulin resistance, and it is well-recognized that macrophages play a major role in such inflammation. In the current review, the molecular mechanisms underlying macrophages, low-grade tissue inflammation, insulin resistance, and T2D are described. Also, the role of macrophages in obesity-induced insulin resistance is presented, and therapeutic drugs and recent advances targeting macrophages for the treatment of T2D are introduced.

摘要

肥胖症的患病率已经达到了惊人的水平，它被认为是几种代谢性疾病的主要危险因素，包括 2 型糖尿病（T2D）、非酒精性脂肪肝、动脉粥样硬化和缺血性心血管疾病。肥胖引起的慢性、低度炎症可能导致胰岛素抵抗，人们已经认识到巨噬细胞在这种炎症中起着主要作用。在本综述中，描述了巨噬细胞、低度组织炎症、胰岛素抵抗和 T2D 的分子机制。还介绍了巨噬细胞在肥胖诱导的胰岛素抵抗中的作用，以及针对巨噬细胞治疗 T2D 的治疗药物和最新进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d12/9562180/d3c1ae29c230/cells-11-03001-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d12/9562180/c4f650116856/cells-11-03001-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d12/9562180/8d11a940c83c/cells-11-03001-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d12/9562180/21bcaf6c4e9c/cells-11-03001-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d12/9562180/d3c1ae29c230/cells-11-03001-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d12/9562180/c4f650116856/cells-11-03001-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d12/9562180/8d11a940c83c/cells-11-03001-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d12/9562180/21bcaf6c4e9c/cells-11-03001-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d12/9562180/d3c1ae29c230/cells-11-03001-g004.jpg

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Macrophages, Chronic Inflammation, and Insulin Resistance.

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[9]
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本文引用的文献

[1]
The Roles of Adipose Tissue Macrophages in Human Disease.

Front Immunol. 2022

[2]
Neutrophils Actively Contribute to Obesity-Associated Inflammation and Pathological Complications.

Cells. 2022-6-10

[3]
Role of Innate lymphoid Cells in Obesity and Insulin Resistance.

Front Endocrinol (Lausanne). 2022

[4]
Transcriptional and Microenvironmental Landscape of Macrophage Transition in Cancer: A Boolean Analysis.

Front Immunol. 2021

[5]
The role of adipose tissue M1/M2 macrophages in type 2 diabetes mellitus.

Diabetol Int. 2020-12-15

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Association between muscle mass and insulin sensitivity independent of detrimental adipose depots in young adults with overweight/obesity.

Int J Obes (Lond). 2020-9

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mTORC2 Signaling Is Necessary for Timely Liver Regeneration after Partial Hepatectomy.

Am J Pathol. 2020-2-5

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Decreases in Circulating Concentrations of Long-Chain Acylcarnitines and Free Fatty Acids During the Glucose Tolerance Test Represent Tissue-Specific Insulin Sensitivity.

Front Endocrinol (Lausanne). 2019-12-17

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DAMPs, PAMPs, and LAMPs in Immunity and Sterile Inflammation.

Annu Rev Pathol. 2019-11-1

[10]
Resolving the fibrotic niche of human liver cirrhosis at single-cell level.

Nature. 2019-10-9

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