Graduate School of Science, Kyoto University, Japan.
Department of Chemistry, University College, London.
Chempluschem. 2021 Mar;86(3):418-433. doi: 10.1002/cplu.202100004.
In recent years, luminescent supramolecular coordination complexes (SCCs), including 2D-metallacycles and 3D-metallacages have been utilised for biomolecular analysis. Unlike small-molecular probes, the dimensions, size, shape, and flexibility of these complexes can easily be tuned by combining ligands designed with particular geometries, symmetries and denticity with metal ions with strong geometrical binding preferences. The well-defined cavities that result, in combination with the other non-covalent interactions that can be programmed into the ligand design, facilitate great selectivity towards guest binding. In this Review we will discuss the application of luminescent metallacycles and cages in the binding and detection of a wide range of biomolecules, such as carbohydrates, proteins, amino acids, and biogenic amines. We aim to explore the effect of the structural diversity of SCCs on the extent of biomolecular sensing, expressed in terms of sensitivity, selectivity and detection range.
近年来，发光超分子配位化合物（SCCs），包括 2D-金属环和 3D-金属笼，已被用于生物分子分析。与小分子探针不同，通过将具有特定几何形状、对称性和齿合度的配体与具有强几何结合偏好的金属离子组合，可以轻松调节这些配合物的尺寸、大小、形状和灵活性。由此产生的定义良好的空腔，结合可以在配体设计中编程的其他非共价相互作用，有利于对客体结合具有很大的选择性。在这篇综述中，我们将讨论发光金属环和笼在广泛的生物分子，如碳水化合物、蛋白质、氨基酸和生物胺的结合和检测中的应用。我们旨在探讨 SCCs 的结构多样性对生物分子传感程度的影响，以灵敏度、选择性和检测范围来表示。
