吡咯霉素，一种新型抗生素：分类、发酵、分离、结构测定及生物学特性

Pyrroxamycin, a new antibiotic taxonomy, fermentation, isolation, structure determination and biological properties.

作者信息

Yano K, Oono J, Mogi K, Asaoka T, Nakashima T

出版信息

J Antibiot (Tokyo). 1987 Jul;40(7):961-9. doi: 10.7164/antibiotics.40.961.

DOI:10.7164/antibiotics.40.961

Abstract

A strain of streptomycete was found to produce a new antibiotic pyrroxamycin. This compound was isolated from the culture broth of Streptomyces sp. S46506. The chemical structure was determined to be 4,5-dichloro-2-(6',8'-dichloro-4'H-1',3'-benzodioxin-4'-yl)-3-nitr opyrrole by its chemical character and 1H and 13C NMR spectral analysis. Pyrroxamycin was active against Gram-positive bacteria and dermatophytes.

摘要

发现一株链霉菌能产生一种新的抗生素吡咯霉素。该化合物是从链霉菌属S46506的培养液中分离得到的。通过化学性质以及氢核磁共振（1H NMR）和碳核磁共振（13C NMR）光谱分析确定其化学结构为4,5-二氯-2-(6',8'-二氯-4'H-1',3'-苯并二恶英-4'-基)-3-硝基吡咯。吡咯霉素对革兰氏阳性菌和皮肤癣菌具有活性。