Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Q221 Mosier Hall, Manhattan, KS 66506, USA.
Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, 305 Coles Hall, 1620 Denison Avenue, Manhattan, KS 66506-5800, USA.
Vet Clin North Am Food Anim Pract. 2022 Nov;38(3):335-346. doi: 10.1016/j.cvfa.2022.08.001.
Liver abscesses are a bacterial infection, which occurs because of entry, via portal vein, of pyogenic bacteria into the hepatic parenchyma. Liver abscesses are a polymicrobial infection; however, Fusobacterium necrophorum, a ruminal bacterium, is the primary etiologic agent. Ruminal acidosis disrupts the protective barrier function of the ruminal epithelium and facilitates entry and colonization of F. necrophorum in the ruminal wall and subsequent entry into the portal circulation. Virulence factors of F. necrophorum contribute to the evasion of host defense mechanisms and cause tissue damage to set up an infection in the liver. The potential role of the hindgut in pathogenesis remains to be investigated.
肝脓肿是一种细菌性感染，是由于化脓性细菌经门静脉进入肝实质而引起的。肝脓肿是一种多种微生物感染，但是，坏死梭杆菌，一种瘤胃酸菌，是主要的病原体。瘤胃酸中毒破坏了瘤胃上皮的保护屏障功能，并促进坏死梭杆菌进入瘤胃壁并随后进入门静脉循环。坏死梭杆菌的毒力因子有助于逃避宿主防御机制，并导致组织损伤，从而在肝脏中引发感染。后肠在发病机制中的潜在作用仍有待研究。
