Division of Endocrinology, Diabetes, Nutrition and Weight Management, 72 East, Concord Street C3 (Room 321 A), Collamore Building, Boston, MA 02118, USA.
Division of Endocrinology, Diabetes and Hypertension, Center for Weight Management and Wellness, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, Suite RFB-2, Brigham and Women's at 221 Longwood, Boston, MA 02115, USA.
Endocrinol Metab Clin North Am. 2022 Dec;51(4):795-815. doi: 10.1016/j.ecl.2022.06.002.
Obesity is a chronic disease characterized by long duration, slow progression, and periods of remission and relapses. Despite the development of effective medical and surgical interventions and millions of people conducting tremendous personal efforts to manage their weight every year, recidivism remains a significant barrier to attaining long-term weight maintenance. This review aimed to explain the underlying physiology of the weight-reduced state including changes in energy balance, adipose tissue, genetic, environmental, and behavioral factors that may predispose individuals to weight regain following weight loss.
肥胖是一种慢性疾病，其特征为病程长、进展缓慢，并伴有缓解和复发期。尽管已经开发出有效的医学和手术干预措施，并且每年都有数百万人为控制体重付出巨大的个人努力，但复胖仍是实现长期体重维持的一个重大障碍。本综述旨在解释减轻体重状态的潜在生理学机制，包括能量平衡、脂肪组织、遗传、环境和行为因素的变化，这些因素可能使个体在减肥后容易体重反弹。
