Li Jian-Ming, Li Lian-Min, Shi Jun-Feng, Li Ting, Wang Qi, Ma Qing-Xia, Zheng Wei, Feng Hai-Feng, Liu Fei, Du Rui
College of Animal Science and Technology, Jilin Agricultural University, Changchun, China.
College of Chinese Medicine Materials, Jilin Agricultural University, Changchun, China.
Front Vet Sci. 2022 Sep 29;9:944282. doi: 10.3389/fvets.2022.944282. eCollection 2022.
Leptospirosis is an acute infectious disease caused by pathogenic bacteria from the genus . The disease is widely distributed throughout China, causing harm to human and animal health. Murine may naturally carry a variety of pathogenic , thus being important sources of infection by humans and livestock. The aim of this study was to assess and analyse the prevalence of and its risk factors in murine. We collected 46 publications published between inception and 2022 through China Knowledge Network (CNKI), VIP Chinese Journal Database, Wanfang Database, PubMed, and ScienceDirect. In these studies, a total of 54,051 murine in 5 regions of China were investigated, and the prevalence of leptospirosis ranged from 1.11 to 35.29%. The prevalence of murine leptospirosis in south China was the highest, at 20.13%, and the lowest in northeast China, at 1.11% ( < 0.05). The prevalence of leptospirosis in male murine was 21.38%, which was significantly higher than that in females (17.07%; < 0.05). Results according to detection method subgroup showed that the prevalence from serological testing was 15.94%, which was significantly higher than that of etiology and molecular biology methods ( < 0.01). In the sample subgroup, the positive rate of serum samples was 15.30%, which was significantly higher than that of tissue samples, at 7.97%. In addition, the influence of different geographical factors on prevalence was analyzed, indicating that the Yangtze River Basin was a high-incidence area for leptospirosis. The study showed that were ubiquitous throughout the country, and factors such as environment, temperature and landform affect the murine distribution and their bacteria carrying rate. We suggest strengthening the continuous monitoring of leptospirosis and taking effective and comprehensive measures such as reducing water contact, vaccinating in high-incidence seasons, and avoiding human contamination caused by water pollution and contact with infected murine.
钩端螺旋体病是由钩端螺旋体属致病细菌引起的一种急性传染病。该病在中国广泛分布，对人类和动物健康造成危害。鼠类可能自然携带多种病原体，因此是人类和家畜的重要感染源。本研究的目的是评估和分析鼠类中钩端螺旋体的流行情况及其危险因素。我们通过中国知网（CNKI）、维普中文期刊数据库、万方数据库、PubMed和ScienceDirect收集了从创刊到2022年期间发表的46篇出版物。在这些研究中，共调查了中国5个地区的54051只鼠类，钩端螺旋体病的患病率在1.11%至35.29%之间。中国南方鼠类钩端螺旋体病的患病率最高，为20.13%，东北地区最低，为1.11%（P<0.05）。雄性鼠类钩端螺旋体病的患病率为21.38%，显著高于雌性（17.07%；P<0.05）。根据检测方法亚组的结果显示，血清学检测的患病率为15.94%，显著高于病因学和分子生物学方法（P<0.01）。在样本亚组中，血清样本的阳性率为15.30%，显著高于组织样本的7.97%。此外，分析了不同地理因素对患病率的影响，表明长江流域是钩端螺旋体病的高发地区。研究表明，钩端螺旋体在全国普遍存在，环境、温度和地形等因素影响鼠类的分布及其带菌率。我们建议加强对钩端螺旋体病的持续监测，并采取有效和全面的措施，如减少与水的接触、在高发季节进行疫苗接种以及避免水污染和接触感染鼠类造成的人类污染。
