Petersen Johannes, Naito Shiho, Kloth Benjamin, Pecha Simon, Zipfel Svante, Alassar Yousuf, Detter Christian, Conradi Lenard, Reichenspurner Hermann, Girdauskas Evaldas
Department of Cardiovascular Surgery, University Heart & Vascular Center, UKE Hamburg, Hamburg, Germany.
Department of Cardiothoracic Surgery, Augsburg University Hospital, Augsburg, Germany.
Front Cardiovasc Med. 2022 Sep 30;9:980074. doi: 10.3389/fcvm.2022.980074. eCollection 2022.
Minimally-invasive (MIS) mitral valve (MV) surgery has become standard therapy in many cardiac surgery centers. While femoral arterial perfusion is the preferred cannulation strategy in MIS mitral valve surgery, retrograde arterial perfusion is known to be associated with an increased risk for cerebral atheroembolism, particularly in atherosclerosis patients. Therefore, antegrade perfusion may be beneficial in such cases. This analysis aimed to compare outcomes of antegrade axillary vs. retrograde femoral perfusion in the MIS mitral valve surgery.
This analysis includes 50 consecutive patients who underwent MIS between 2016 and 2020 using arterial cannulation of right axillary artery (Group A) due to severe aortic arteriosclerosis. Perioperative outcomes of the study group were compared with a historical control group of retrograde femoral perfusion (Group F) which was adjusted for age and gender ( = 50). Primary endpoint of the study was in-hospital mortality and perioperative cerebrovascular events.
Patients in group A had a significantly higher perioperative risk as compared to Group F (EuroSCORE II: 3.9 ± 2.5 vs. 1.6 ± 1.5; = 0.001; STS-Score: 2.1 ± 1.4 vs. 1.3 ± 0.6; = 0.023). Cardiopulmonary bypass time (group A: 172 ± 46; group F: 178 ± 51 min; = 0.627) and duration of surgery (group A: 260 ± 65; group F: 257 ± 69 min; = 0.870) were similar. However, aortic cross clamp time was significantly shorter in group A as compared to group F (86 ± 20 vs. 111 ± 29 min, < 0.001). There was no perioperative stroke in either groups. In-hospital mortality was similar in both groups (group A: 1 patient; group F: 0 patients; = 0.289). In group A, one patient required central aortic repair due to intraoperative aortic dissection. No further cardiovascular events occurred in Group A patients.
Selective use of antegrade axillary artery perfusion in patients with systemic atherosclerosis shows similar in-hospital outcomes as compared to lower risk patients undergoing retrograde femoral perfusion. Patients with higher perioperative risk and severe atherosclerosis can be safely treated the minimally invasive approach with antegrade axillary perfusion.
微创二尖瓣手术已成为许多心脏外科中心的标准治疗方法。虽然股动脉灌注是微创二尖瓣手术中首选的插管策略,但逆行动脉灌注已知与脑动脉粥样硬化栓塞风险增加相关,尤其是在动脉粥样硬化患者中。因此,顺行灌注在这种情况下可能有益。本分析旨在比较微创二尖瓣手术中顺行腋动脉灌注与逆行股动脉灌注的结果。
本分析纳入了2016年至2020年间连续50例因严重主动脉动脉硬化而采用右腋动脉动脉插管进行微创二尖瓣手术的患者(A组)。将研究组的围手术期结果与经年龄和性别调整的逆行股动脉灌注历史对照组(F组,n = 50)进行比较。研究的主要终点是住院死亡率和围手术期脑血管事件。
与F组相比,A组患者的围手术期风险显著更高(欧洲心脏手术风险评估系统II:3.9±2.5对1.6±1.5;P = 0.001;胸外科医师协会评分:2.1±1.4对1.3±0.6;P = 0.023)。体外循环时间(A组:172±46;F组:178±51分钟;P = 0.627)和手术持续时间(A组:260±65;F组:257±69分钟;P = 0.870)相似。然而,A组的主动脉阻断时间明显短于F组(86±20对111±29分钟,P < 0.001)。两组均未发生围手术期卒中。两组的住院死亡率相似(A组:1例患者;F组:0例患者;P = 0.289)。在A组中,1例患者因术中主动脉夹层需要进行主动脉中央修复。A组患者未发生进一步的心血管事件。
与接受逆行股动脉灌注的低风险患者相比,在全身性动脉粥样硬化患者中选择性使用顺行腋动脉灌注显示出相似的住院结局。围手术期风险较高且患有严重动脉粥样硬化的患者可以通过顺行腋动脉灌注的微创方法安全治疗。